Description

3-Azageranylgeranyl Diphosphate is a synthetic, high-purity biochemical analog of geranylgeranyl diphosphate (GGPP), where a nitrogen atom replaces a carbon in the isoprenoid chain. This compound is a critical research tool for enzymology and metabolic pathway studies, particularly in the investigation of protein prenylation and terpenoid biosynthesis. It is essential for scientists and R&D teams in pharmaceutical discovery, agricultural chemistry, and advanced biochemical research who require precise, well-characterized substrates and inhibitors.

Application

• Enzymology Research: Serves as a substrate analog for studying the activity and inhibition of geranylgeranyl transferases (GGTases) and other prenyltransferases.
• Drug Discovery: Used in high-throughput screening assays to identify novel inhibitors targeting protein prenylation pathways relevant to cancer, neurodegenerative diseases, and parasitic infections.
• Metabolic Pathway Analysis: A key tool for probing and modulating the terpenoid biosynthesis pathway in both mammalian and plant systems.
• Biochemical Standard: Employed as a certified reference material for analytical method development and validation in LC-MS or HPLC assays.
• Academic Research: Facilitates fundamental studies on the mechanism of protein lipid modification and its role in cellular signaling and membrane localization.

Basic Information

Product Name	3-Azageranylgeranyl Diphosphate
CAS No.	143907-82-8
Molecular Formula	C20H37N2O7P2- (Ammonium salt form common)
Molecular Weight	~502.46 g/mol (Free acid)
Synonyms	3-Aza-GGPP; 3-Azageranylgeranyl pyrophosphate; Azageranylgeranyl diphosphate; Aza-GGPP; (2E,6E,10E)-14-Aza-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraene-1-diphosphoric acid; Prenyltransferase inhibitor analog; GGPP analog, nitrogen-containing
EINECS	Contact for details

Quality Control

Every batch of 3-Azageranylgeranyl Diphosphate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment includes comprehensive characterization by NMR, HPLC, and MS to meet the exacting standards of research and development. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with each order.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a desiccated environment. This material is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.