Description

(R)-2-Hydroxybutyl Tosylate is a high-purity chiral building block and pharmaceutical intermediate of significant synthetic utility. Its value lies in its role as a versatile electrophile for the stereoselective introduction of the (R)-2-hydroxybutyl moiety, enabling the synthesis of complex molecules with defined stereochemistry. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and fine chemical industries engaged in asymmetric synthesis and the development of active ingredients.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of active pharmaceutical ingredients (APIs) requiring specific stereochemistry.
• Asymmetric Synthesis: Used in nucleophilic substitution reactions to construct carbon-oxygen and carbon-carbon bonds with retention of configuration.
• Agrochemical Research: Building block for developing chiral herbicides, fungicides, and plant growth regulators.
• Ligand and Catalyst Preparation: Intermediate in the synthesis of chiral ligands for asymmetric catalysis.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals, flavors, and fragrances.
• Academic & Process Chemistry: Valuable reagent for methodological development and scale-up studies in organic synthesis.

Basic Information

Product Name	(R)-2-Hydroxybutyl Tosylate
CAS No.	143693-24-7
Molecular Formula	C11H16O4S
Molecular Weight	244.31 g/mol
Synonyms	(R)-2-Hydroxybutyl p-Toluenesulfonate; (R)-1-Butanol, 2-hydroxy-, 1-(4-methylbenzenesulfonate); (R)-2-Butanol, 1-tosylate; (R)-1-Tosyloxy-2-butanol; (2R)-2-Hydroxybutyl 4-methylbenzenesulfonate; p-Toluenesulfonic Acid (R)-2-Hydroxybutyl Ester; (R)-HBT
EINECS	Contact for details

Quality Control

Our (R)-2-Hydroxybutyl Tosylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.