Description

Guanosine 5'-Diphospho-α-L-Fucose Sodium Salt is a high-purity nucleotide sugar donor essential for enzymatic glycosylation reactions. This compound serves as a critical substrate for fucosyltransferases, enabling the site-specific transfer of L-fucose to glycoproteins, glycolipids, and oligosaccharides. It is a vital reagent for researchers and manufacturers in glycobiology research, biopharmaceutical development, and the synthesis of complex carbohydrates for therapeutic and diagnostic applications.

Application

• Enzymatic Synthesis of Glycoconjugates: As a key substrate for in vitro fucosylation to produce defined glycan structures for research and therapeutic use.
• Biopharmaceutical Development: Used in the characterization and production of monoclonal antibodies, enzymes, and other protein therapeutics where specific fucosylation patterns impact efficacy and pharmacokinetics.
• Glycoengineering: Essential for modifying cell surface glycans to study cell-cell interactions, signaling, and for developing cell-based therapies.
• Diagnostic Reagent Production: Employed in the synthesis of carbohydrate antigens and probes for diagnostic assays and biomarker discovery.
• Enzyme Activity Assays: Serves as a co-substrate in high-throughput screening and kinetic studies of fucosyltransferase enzymes.
• Academic & Industrial Research: A fundamental tool in structural biology, chemical biology, and metabolic pathway studies related to fucose metabolism.

Basic Information

Product Name	Guanosine 5'-Diphospho-α-L-Fucose Sodium Salt
CAS No.	143394-77-8
Molecular Formula	C16H23N5O16P2Na2 • xH2O
Molecular Weight	Approx. 677.3 (Anhydrous)
Synonyms	GDP-Fucose Sodium Salt; Guanosine Diphosphate Fucose Sodium Salt; GDP-α-L-Fucose Sodium Salt; GDP-L-Fucose Sodium Salt; Guanosine 5'-(trihydrogen diphosphate) P'→5'-ester with 6-deoxy-α-L-galactopyranose, disodium salt; 6-Deoxy-α-L-galactopyranosyl guanosine diphosphate disodium salt; α-L-Fucose-1-guanosine diphosphate disodium salt
EINECS	Contact for details

Quality Control

Our Guanosine 5'-Diphospho-α-L-Fucose Sodium Salt is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for sensitive biochemical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant guidelines for research and process development use.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95% (Anhydrous basis)
Water Content (KF)	≤ 5.0%
NMR Profile	Consistent with structure
Biological Activity	Suitable for enzyme assays

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.