Description

Lerisetron is a potent and selective serotonin 5-HT3 receptor antagonist, identified by CAS NO 143257-98-1. This compound is of significant interest in pharmaceutical research and development for its potential to modulate serotonin pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of new therapeutic agents targeting nausea, vomiting, and certain neurological conditions.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced active pharmaceutical ingredients (APIs) targeting 5-HT3 receptors.
• Neurological Research: Used in preclinical and clinical research to study the role of serotonin in the central nervous system and its implications for various disorders.
• Antiemetic Drug Development: A critical component in R&D programs focused on creating new treatments for chemotherapy-induced and postoperative nausea and vomiting (CINV & PONV).
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Biochemical Assays: Utilized in in vitro studies to investigate receptor binding affinity, selectivity, and pharmacological profiles.

Basic Information

Product Name	Lerisetron
CAS No.	143257-98-1
Molecular Formula	C19H21FN4O
Molecular Weight	340.40 g/mol
Synonyms	Lerisetron; 143257-98-1; (3aS,9bR)-8-Fluoro-3,3a,4,9b-tetrahydro-1H-pyrrolo[3,2-c]quinolin-2(3H)-one; F 11356; F11356; Lerisetronum; UNII-2V7N2F8J7W; 2V7N2F8J7W
EINECS	Contact for details

Quality Control

Our Lerisetron is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and stringent control of residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure full traceability and compliance with your research or cGMP requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.