Description

Hexanoic Acid-N, n-Hydroxysuccinimide Ester, [1-14C] is a carbon-14 labeled, activated ester derivative of hexanoic acid, specifically designed for efficient bioconjugation and tracer studies. This compound is critical for researchers requiring high-specific-activity radiolabeling to track molecular interactions, metabolism, and pharmacokinetics with precision. It is primarily utilized by pharmaceutical R&D teams, contract research organizations (CROs), and academic laboratories focused on developing and characterizing novel therapeutic agents, including antibody-drug conjugates (ADCs) and other targeted biologics.

Application

• Radiolabeled Tracer Synthesis: Acts as a key intermediate for introducing a carbon-14 label into target molecules for absorption, distribution, metabolism, and excretion (ADME) studies.
• Bioconjugation & Protein Labeling: Used to covalently attach hexanoic acid chains or other payloads to amino groups on proteins, peptides, and antibodies under mild aqueous conditions.
• Antibody-Drug Conjugate (ADC) Research: Facilitates the radiolabeling of linker-payload constructs to study ADC stability, drug release kinetics, and tumor targeting efficiency in preclinical models.
• Metabolic Pathway Analysis: Enables the tracing of fatty acid metabolism and incorporation into more complex lipids or other biomolecules in biochemical research.
• Quality Control & Reference Standard: Serves as an authenticated radiolabeled standard for analytical method development and validation in GLP/GMP environments.

Basic Information

Product Name	Hexanoic Acid-N, n-Hydroxysuccinimide Ester, [1-14C]
CAS No.	143152-78-7
Molecular Formula	C₁₀H₁₄¹⁴CNO₄
Molecular Weight	~229.68 g/mol (unlabeled)
Synonyms	N-Hexanoic Acid Succinimidyl Ester, [1-14C]; [1-14C]Caproic Acid N-Hydroxysuccinimide Ester; 6-([1-14C]Hexanoyloxy)-2,5-pyrrolidinedione; [1-14C]Hexanoic Acid NHS Ester; [carbonyl-14C]N-Succinimidyl Hexanoate; NSC 6-14C Labeled NHS-Caproate; Activated [1-14C]Caproate
EINECS	Contact for details

Quality Control

Every batch of our carbon-14 labeled materials is manufactured and tested under strict quality systems to ensure isotopic and chemical purity for critical research. Comprehensive analysis includes radiochemical purity by HPLC, specific activity determination, and chemical identity confirmation. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all release specifications and traceability to relevant standards.

Storage

Preserve in a tightly closed container, protected from light. Store at or below -20°C. This product is strictly light-sensitive (protect from all light exposure). Store in a dedicated, appropriately shielded facility for radioactive materials in accordance with local regulations. Allow the vial to reach room temperature in a dark environment before opening.

Specification

Item	Specification
Appearance	White to off-white solid or solution
Identification (IR/NMR)	Conforms to structure
Radiochemical Purity (HPLC)	≥ 98%
Chemical Purity (HPLC)	≥ 95%
Specific Activity	50-60 mCi/mmol (Contact for exact value)
Solvent (if supplied as solution)	Anhydrous Acetonitrile or DMSO
Concentration (if supplied as solution)	1.0 mCi/mL ± 10%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.