Description

n-Acetylglucosaminyl-n-Acetylmuramyl(Tripeptide)-Pyrophosphate-Undecaprenol is a critical biosynthetic intermediate in bacterial cell wall peptidoglycan assembly. This specialized lipid-linked precursor is essential for research into the fundamental mechanisms of bacterial growth and division. It is primarily utilized by pharmaceutical researchers and microbiologists for target identification, enzyme inhibition studies, and the development of novel antibacterial agents targeting the cell wall synthesis pathway.

Application

• Biochemical Research: As a key substrate for studying the transglycosylation and transpeptidation reactions in peptidoglycan biosynthesis.
• Antibiotic Discovery: High-value screening tool for identifying and characterizing inhibitors of enzymes like MraY (translocase I) and MurG (transglycosylase).
• Enzyme Kinetics: Used to determine the activity and specificity of membrane-bound enzymes involved in the cell wall assembly pathway.
• Mechanistic Studies: Investigating the mode of action of existing antibiotics such as vancomycin and moenomycin.
• Synthetic Biology: A building block for reconstructing and studying minimal cell wall synthesis systems in vitro.
• Vaccine Adjuvant Research: Exploring derivatives of peptidoglycan precursors for potential immunomodulatory properties.

Basic Information

Product Name	n-Acetylglucosaminyl-n-Acetylmuramyl(Tripeptide)-Pyrophosphate-Undecaprenol
CAS No.	142714-10-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Lipid II (Tripeptide variant); Undecaprenyl-diphosphoryl-MurNAc-(pentapeptide)-GlcNAc (Tripeptide); Park's Nucleotide (extended lipid form); C55-PP-MurNAc-(L-Ala-D-Glu-m-DAP)-GlcNAc; UDP-MurNAc-pentapeptide-GlcNAc-PP-Undecaprenol (Tripeptide); Bacterial Cell Wall Precursor Lipid II (Tripeptide); NAG-NAM-(Tripeptide)-PP-Undecaprenol
EINECS	Contact for details

Quality Control

Our n-Acetylglucosaminyl-n-Acetylmuramyl(Tripeptide)-Pyrophosphate-Undecaprenol is produced and handled under stringent conditions to ensure batch-to-batch consistency and research-grade purity. Quality is verified through a combination of analytical techniques including HPLC, mass spectrometry (MS), and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and requires careful handling to maintain stability. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 2.0%
Solubility	Soluble in chloroform/methanol/water mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.