Description

Guanosine 3',5'-Cyclic Monophosphate, 2'-o-Anthraniloyl-, Sodium Salt is a chemically modified, fluorescently labeled derivative of cyclic GMP (cGMP), a crucial secondary messenger in cellular signal transduction. This specialized compound is engineered for high-sensitivity detection and quantification in biochemical research, offering distinct advantages over non-labeled analogs. It is primarily utilized by researchers and scientists in the fields of molecular biology, pharmacology, and diagnostics for studying cyclic nucleotide-dependent pathways, enzyme kinetics, and high-throughput screening assays.

Application

• Biochemical Research & Assay Development: As a fluorescent probe for the sensitive detection and quantification of cGMP and related enzymatic activities, such as phosphodiesterases (PDEs) and guanylyl cyclases.
• Cellular Signaling Studies: Investigation of intracellular signal transduction pathways involving cGMP as a second messenger, including those related to cardiovascular function, vision, and neural plasticity.
• High-Throughput Screening (HTS): A key reagent in fluorescence-based assays for drug discovery campaigns targeting cGMP-metabolizing enzymes or cGMP-binding proteins.
• Diagnostic Kit Manufacturing: Potential use as a critical raw material in the development of diagnostic kits for research purposes, measuring cGMP levels in biological samples.
• Enzyme Kinetics & Inhibition Studies: Used to study the mechanism, activity, and inhibition profiles of enzymes that interact with or modify cyclic nucleotides.

Basic Information

Product Name	Guanosine 3',5'-Cyclic Monophosphate, 2'-o-Anthraniloyl-, Sodium Salt
CAS No.	142702-30-5
Molecular Formula	C22H20N6NaO9P
Molecular Weight	566.39 g/mol
Synonyms	2'-O-Anthraniloyl-cGMP sodium salt; 2'-O-Ant-cGMP sodium salt; Fluorescent cGMP derivative; Anthraniloyl-labeled cGMP; 2'-O-(2-Aminobenzoyl)guanosine 3',5'-cyclic monophosphate sodium salt; cGMP-ANT, Na+ salt; 2'-O-AB-cGMP sodium salt
EINECS	Contact for details

Quality Control

Our Guanosine 3',5'-Cyclic Monophosphate, 2'-o-Anthraniloyl-, Sodium Salt is produced under stringent conditions to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing specific results is provided with every shipment to guarantee compliance with your research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange lyophilized powder
Identification (HPLC/UV)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Fluorescence Properties	Excitation/Emission maxima typical for anthraniloyl label

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.