Description

Adenosine 3',5'-Cyclic Monophosphate, 2'-o-Anthraniloyl-, Sodium Salt is a fluorescently labeled derivative of cyclic adenosine monophosphate (cAMP), a fundamental secondary messenger in cellular signal transduction. This modified compound is crucial for advanced biochemical research, enabling the real-time visualization and quantification of cAMP dynamics in live cells and enzymatic assays. It is an essential tool for researchers and developers in pharmaceutical discovery, molecular biology, and diagnostic assay development, particularly for studying G-protein-coupled receptor (GPCR) pathways and phosphodiesterase activity.

Application

• Biochemical Research & Assay Development: As a high-affinity fluorescent tracer in competitive binding assays (e.g., fluorescence polarization, FRET) for cAMP detection.
• Drug Discovery Screening: Used in high-throughput screening (HTS) platforms to identify novel agonists or antagonists targeting adenylate cyclase or phosphodiesterases.
• Cellular Signaling Studies: Enables real-time, non-invasive monitoring of intracellular cAMP fluctuations in response to hormonal or pharmacological stimuli.
• Diagnostic Kit Manufacturing: Serves as a key component in the production of research-use-only (RUO) and diagnostic kits for cellular pathway analysis.
• Enzyme Activity Analysis: Acts as a substrate for studying the kinetics and inhibition of phosphodiesterases (PDEs).
• Academic & Institutional Research: Fundamental tool for investigating signal transduction mechanisms in cardiovascular, neurological, and metabolic disorders.

Basic Information

Item	Detail
Product Name	Adenosine 3',5'-Cyclic Monophosphate, 2'-o-Anthraniloyl-, Sodium Salt
CAS No.	142702-29-2
Molecular Formula	C22H20N6NaO8P
Molecular Weight	550.39 g/mol
Synonyms	2'-O-Anthraniloyladenosine 3',5'-cyclic monophosphate sodium salt; 2'-O-ABA-cAMP; Fluorescent cAMP; Anthraniloyl-cAMP, sodium salt; cAMP, 2'-O-(2-anthraniloyl); 2'-O-(N-Amidinoanthraniloyl)adenosine-3',5'-cyclic monophosphate sodium salt; AAB-cAMP Na+
EINECS	Contact for details

Quality Control

Every batch of our Adenosine 3',5'-Cyclic Monophosphate, 2'-o-Anthraniloyl-, Sodium Salt is manufactured and tested under strict quality management systems. We guarantee high purity and consistent performance for sensitive research applications. Comprehensive analytical testing, including HPLC for purity and spectral analysis for identity confirmation, is performed. A detailed Certificate of Analysis (COA) documenting purity, absorbance/fluorescence characteristics, and other critical parameters is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	Yellow to orange lyophilized powder
Identification (HPLC & UV/FL)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Extinction Coefficient (ε)	~5,500 M-1cm-1 at 316 nm (in aqueous buffer)
Fluorescence Properties	Excitation ~316 nm, Emission ~418 nm (pH dependent)
Water Content (KF)	≤ 5.0 %
Solubility	Soluble in water, DMSO, and aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.