Description

S-(2-Bromo-2-Chloro-1,1-Difluoroethyl)Glutathione is a specialized biochemical derivative of the tripeptide glutathione, featuring a halogenated ethyl moiety. This compound is of significant interest in biochemical and pharmacological research, particularly as a reference standard or a key intermediate in the study of metabolic pathways and detoxification mechanisms involving glutathione S-transferase enzymes. It is primarily utilized by research institutions, pharmaceutical development laboratories, and contract research organizations (CROs) engaged in advanced metabolite identification, toxicology studies, and the synthesis of novel bioactive molecules.

Application

• Biochemical Research Standard: Serves as a critical analytical reference standard for the identification and quantification of glutathione-derived metabolites in complex biological matrices.
• Metabolite Synthesis & Characterization: Used as a synthetic intermediate or a model compound in the study of xenobiotic metabolism and the formation of glutathione conjugates.
• Enzymology Studies: Employed as a substrate or inhibitor in in vitro assays to investigate the activity and specificity of glutathione S-transferase (GST) enzymes.
• Toxicology & Drug Safety Assessment: Aids in understanding the detoxification pathways and potential reactive intermediates formed during the metabolism of halogenated compounds.
• Pharmaceutical Impurity Profiling: Used in the development and validation of analytical methods to monitor for potential glutathione-related impurities or degradation products in active pharmaceutical ingredients (APIs).
• Proteomics & Biomarker Discovery: Can be utilized in studies exploring protein S-glutathionylation, a post-translational modification relevant to redox signaling and cellular stress responses.

Basic Information

Product Name	S-(2-Bromo-2-Chloro-1,1-Difluoroethyl)Glutathione
CAS No.	142628-07-7
Molecular Formula	C₁₅H₂₂BrClF₂N₃O₆S
Molecular Weight	528.77 g/mol
Synonyms	Glutathione, S-(2-bromo-2-chloro-1,1-difluoroethyl)-; S-(2-Bromo-2-chloro-1,1-difluoroethyl)-L-glutathione; L-Glutathione, S-(2-bromo-2-chloro-1,1-difluoroethyl)-; 2-Bromo-2-chloro-1,1-difluoroethylglutathione; Halothane-Glutathione Conjugate; GST Metabolite Reference Standard
EINECS	Contact for details

Quality Control

Our S-(2-Bromo-2-Chloro-1,1-Difluoroethyl)Glutathione is produced under a strict quality management system. Each batch undergoes comprehensive analytical characterization using techniques including HPLC, NMR, and mass spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are available upon request, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤5.0%
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.