Description

Sp-Cyclic Amps (Sodium Salt) is a high-purity, cell-permeable analog of cyclic adenosine monophosphate (cAMP) specifically designed for biochemical and pharmacological research. This compound is a crucial tool for studying intracellular signal transduction pathways mediated by protein kinase A (PKA) and other cAMP-dependent processes. It is essential for researchers and developers in the fields of pharmaceutical discovery, molecular biology, and cell signaling research who require reliable and potent activators of cAMP-responsive elements.

Application

• Biochemical Research: As a potent and specific activator of Protein Kinase A (PKA) for in vitro kinase assays and enzyme studies.
• Cell Signaling Studies: To investigate cAMP-mediated pathways in cell culture models, including gene expression, metabolism, and ion channel regulation.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) assays to identify novel agonists or antagonists of cAMP signaling for therapeutic targets.
• Neuroscience Research: For studying the role of cAMP in neuronal plasticity, memory formation, and neurotransmitter release.
• Cardiovascular Research: To examine cAMP's effects on cardiac muscle contractility and vascular smooth muscle relaxation.
• Metabolic Disease Models: Applied in research on insulin secretion, gluconeogenesis, and lipolysis where cAMP is a key secondary messenger.

Basic Information

Product Name	Sp-Cyclic Amps (Sodium Salt)
CAS No.	142439-95-0
Molecular Formula	C₁₀H₁₁N₅NaO₆P
Molecular Weight	351.19 g/mol
Synonyms	Sp-cAMPS sodium salt; Adenosine 3',5'-cyclic monophosphorothioate, Sp-isomer, sodium salt; (Sp)-Adenosine 3',5'-cyclic monophosphorothioate sodium salt; Sp-cyclic adenosine monophosphorothioate sodium salt; cAMP-Sp, sodium salt; Sp-cAMPS, Na salt; 8-(4-Chlorophenylthio)-Sp-cAMPS (common research analog name); Protein Kinase A Activator (Sp-isomer)
EINECS	Contact for details

Quality Control

Our Sp-Cyclic Amps (Sodium Salt) is manufactured under strict quality systems to ensure batch-to-batch consistency and high biological activity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and biological potency. We adhere to rigorous analytical standards suitable for research and development applications, with specifications tailored to meet the demands of critical life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Biological Activity	Confirmed in PKA activation assay
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.