Description

n-(2-Amino-3-(4-Isothiocyanatophenyl)Propyl)Cyclohexane-1,2-Diamine-N,N',N',N'',N''-Pentaacetic Acid is a specialized bifunctional chelating agent and linker molecule, primarily used for the conjugation of biomolecules to metal ions. Its core value lies in its ability to form exceptionally stable complexes with a wide range of metal cations, particularly lanthanides and transition metals, while providing a reactive isothiocyanate group for covalent attachment to proteins and antibodies. This compound is essential for researchers and manufacturers in the fields of diagnostic imaging, targeted radiotherapy, and advanced immunoassays, where precise and stable labeling is critical.

Application

• Radiopharmaceuticals: As a bifunctional chelator for labeling monoclonal antibodies, peptides, and other targeting vectors with diagnostic (e.g., 111In, 68Ga) or therapeutic (e.g., 177Lu, 90Y) radionuclides.
• In Vitro Diagnostics (IVD): Conjugation to enzymes, antibodies, or other proteins for use in time-resolved fluorescence immunoassays (TRFIA) and other sensitive detection platforms utilizing lanthanide chelates.
• Magnetic Resonance Imaging (MRI) Contrast Agents: Development of targeted MRI contrast agents by linking the chelator, loaded with gadolinium or other paramagnetic ions, to specific biological targets.
• Research & Development: A key reagent in chemical biology and bioconjugation research for creating stable metal-protein conjugates for structural studies, cellular tracking, and probe development.
• Theragnostic Agents: Enabling the creation of paired diagnostic and therapeutic agents using the same targeting molecule labeled with different isotopes of the same metal.

Basic Information

Product Name	n-(2-Amino-3-(4-Isothiocyanatophenyl)Propyl)Cyclohexane-1,2-Diamine-N,N',N',N'',N''-Pentaacetic Acid
CAS No.	142434-84-2
Molecular Formula	C24H33N5O10S
Molecular Weight	583.61 g/mol
Synonyms	Cyclohexane-1,2-diamine-N,N,N',N',N''-pentaacetic acid, 2-[2-[4-(isothiocyanatomethyl)phenyl]ethyl] derivative; p-SCN-Bn-CHX-A''-DTPA; CHX-A''-DTPA p-SCN-Bn; 2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid derivative (common structural class reference); Bifunctional Chelator CHX-A''-DTPA; (R)-2-((4-Isothiocyanatobenzyl)diethylenetriaminepentaacetic acid; S-2-(4-Isothiocyanatobenzyl)diethylenetriamine pentaacetic acid; Isothiocyanatobenzyl-CHX-A''-DTPA
EINECS	Contact for details

Quality Control

This high-purity chemical is manufactured under strict quality control protocols suitable for research and diagnostic applications. Each batch is characterized to ensure identity, purity, and functional integrity. A comprehensive Certificate of Analysis (COA) is provided, detailing results from HPLC, NMR, and mass spectrometry. We support compliance with cGMP guidelines for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term stability, store under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Functional Integrity (Chelation Test)	Pass
Isothiocyanate Group Content	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.