Description

1-(5'-Fluoro-6'-Hydroxy-5',6'-Dihydrouracil-5'-Yl)-5-Fluorouracil is a specialized fluorinated uracil derivative, representing a key intermediate in advanced pharmaceutical synthesis. This compound matters for its role in developing novel therapeutic agents, particularly in oncology research, where precise molecular structures are critical for efficacy and safety. It is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on nucleoside chemistry and anticancer drug development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel fluoropyrimidine-based anticancer drugs and prodrugs.
• Oncology Research: Used in biochemical and pharmacological studies to investigate mechanisms of action and structure-activity relationships (SAR) of fluorouracil analogs.
• Nucleoside Chemistry: Serves as a modified nucleoside precursor for the development of targeted therapies and diagnostic agents.
• Academic & Contract Research: Employed in university and CRO laboratories for medicinal chemistry projects and pathway inhibition studies.
• Process Development: Utilized by process chemists for scaling up synthetic routes and optimizing manufacturing protocols for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1-(5'-Fluoro-6'-Hydroxy-5',6'-Dihydrouracil-5'-Yl)-5-Fluorouracil
CAS No.	142237-28-3
Molecular Formula	C9H8F2N4O5
Molecular Weight	290.18 g/mol
Synonyms	5-Fluoro-1-[(5S,6R)-5-fluoro-6-hydroxy-5,6-dihydro-2,4(1H,3H)-pyrimidinedion-5-yl]-2,4(1H,3H)-pyrimidinedione; 1-[(5S,6R)-5-Fluoro-6-hydroxy-5,6-dihydro-2,4(1H,3H)-pyrimidinedion-5-yl]-5-fluorouracil; 5-FU Dimer Derivative; Fluorouracil Dihydroxy Dimer; 5-Fluoro-1-(5-fluoro-6-hydroxy-5,6-dihydro-2,4-dioxo-1,3-diazinan-5-yl)pyrimidine-2,4(1H,3H)-dione
EINECS	Contact for details

Quality Control

Our 1-(5'-Fluoro-6'-Hydroxy-5',6'-Dihydrouracil-5'-Yl)-5-Fluorouracil is produced under controlled conditions to ensure high purity and batch-to-batch consistency suitable for research and development. All products undergo rigorous quality testing, including advanced chromatographic and spectroscopic methods, to ensure compliance with stringent internal specifications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.