Description

o-Desmethyl Carvedilol β-D-Glucuronide is a key glucuronidated metabolite of the widely used β-blocker and vasodilator, Carvedilol. This compound is of critical importance in pharmaceutical research and development, particularly for pharmacokinetic studies, drug metabolism and safety (DMPK) assessments, and as a certified reference standard. It is primarily needed by pharmaceutical companies, contract research organizations (CROs), and analytical laboratories engaged in bioanalytical method development, clinical trial support, and regulatory submission processes.

Application

• Pharmacokinetic and Bioanalytical Research: Used as a certified reference standard for the quantitative analysis of carvedilol metabolites in biological matrices (e.g., plasma, urine) via LC-MS/MS or HPLC.
• Drug Metabolism and Pharmacokinetics (DMPK): Essential for studying the Phase II conjugation pathways and metabolic clearance mechanisms of carvedilol.
• Clinical Trial Support: Serves as a critical calibrator and quality control material in bioanalytical assays supporting clinical studies.
• Impurity Profiling and Characterization: Used to identify and quantify this specific metabolite as a potential impurity in active pharmaceutical ingredient (API) batches.
• Regulatory Compliance and Submission: Provides a traceable standard for generating data required by regulatory agencies like the FDA and EMA.
• Toxicology Studies: Aids in understanding the safety profile and excretion pathways of carvedilol and its metabolites.

Basic Information

Product Name	o-Desmethyl Carvedilol β-D-Glucuronide
CAS No.	142227-50-7
Molecular Formula	C30H38N2O10
Molecular Weight	586.63 g/mol
Synonyms	4-(3-Carbazol-4-yloxy-2-hydroxypropylamino)-6-(2-methoxyphenoxy)hexyl β-D-Glucopyranosiduronic Acid; Carvedilol Metabolite M7; 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol Glucuronide; o-Desmethyl Carvedilol Glucuronide; 5'-(2-Hydroxy-3-((2-(o-methoxyphenoxy)ethyl)amino)propoxy)-9H-carbazol-4-yl β-D-Glucopyranosiduronic Acid; BM 910228 Glucuronide; BM-910228 Glucuronide
EINECS	Contact for details

Quality Control

Our o-Desmethyl Carvedilol β-D-Glucuronide is manufactured under strict quality control protocols suitable for research and analytical applications. Each batch is characterized and tested using advanced analytical techniques to ensure high purity and structural identity. A comprehensive Certificate of Analysis (COA) is provided, detailing results for purity (HPLC), identification (NMR, MS), and related substances. We support compliance with ICH guidelines for stability and impurity profiling.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below. Allow the product to equilibrate to room temperature before opening to minimize moisture condensation. The container should be stored in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Related Substances (HPLC)	Individual impurity ≤2.0%
Total Impurities	≤5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.