Description

Indisetron CAS NO 141549-75-9 is a selective serotonin 5-HT3 receptor antagonist, a class of compounds known for their potent antiemetic properties. This high-purity active pharmaceutical ingredient (API) is critical for ensuring the efficacy and safety of finished pharmaceutical formulations. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of medications to prevent nausea and vomiting, particularly those induced by chemotherapy, radiotherapy, and post-operative conditions.

Application

• Pharmaceutical API: Core active ingredient in the manufacture of antiemetic injectable solutions and oral formulations.
• Oncology Supportive Care: Prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
• Postoperative Nausea and Vomiting (PONV) Management: Key component in medications used to control nausea following surgical procedures.
• Radiotherapy-Induced Emesis Control: Used in formulations to manage nausea associated with radiation therapy.
• Research & Development: Reference standard and building block in pharmacological studies and the development of new therapeutic agents.
• Formulation Development: Used in pre-formulation studies, stability testing, and the development of generic drug products.

Basic Information

Product Name	Indisetron
CAS No.	141549-75-9
Molecular Formula	C20H21N3O2
Molecular Weight	335.40 g/mol
Synonyms	Indisetron; 141549-75-9; (3aS,9aR)-3-[(1-Methyl-1H-indol-3-yl)methyl]-2,3,3a,4,5,9a-hexahydro-1H-benz[e]isoindol-1-one; Y-25130; Y25130; UNII-9J8U3S6Z4F; 9J8U3S6Z4F; (3aS,9aR)-3-[(1-Methylindol-3-yl)methyl]-2,3,3a,4,5,9a-hexahydro-1H-benz[e]isoindol-1-one
EINECS	Contact for details

Quality Control

Our Indisetron is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is hygroscopic (moisture-sensitive) and should be kept in a dry environment.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.