Description

(3β)-9,17α-Dihydroxy-21β-[[(16E)-16,17-Didehydro-17-Methoxy-16-(Methoxycarbonyl)-9-Hydroxycorynan]-10-Yl]Yohimban-16α-Carboxylic Acid Methyl Ester CAS NO 141544-39-0 is a complex indole alkaloid derivative of significant interest in advanced pharmaceutical research and development. This high-purity compound serves as a critical intermediate or reference standard for the synthesis and study of novel bioactive molecules targeting neurological and cardiovascular systems. It is primarily sought by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of new therapeutic agents. The compound's intricate structure makes it a valuable scaffold for medicinal chemistry and pharmacological studies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of complex active pharmaceutical ingredients (APIs), particularly those with neurological activity.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development, validation, and impurity profiling in related pharmaceutical products.
• Medicinal Chemistry Research: Employed as a core scaffold or precursor in drug discovery programs to explore structure-activity relationships (SAR) and develop new candidate molecules.
• Biochemical Research: Utilized in in-vitro studies to investigate interactions with biological targets such as receptors or enzymes, aiding in the understanding of specific biochemical pathways.
• Process Development: Acts as a critical material in the scale-up and optimization of synthetic routes for the production of related alkaloid-based compounds under Good Manufacturing Practice (GMP) conditions.

Basic Information

Item	Details
Product Name	(3β)-9,17α-Dihydroxy-21β-[[(16E)-16,17-Didehydro-17-Methoxy-16-(Methoxycarbonyl)-9-Hydroxycorynan]-10-Yl]Yohimban-16α-Carboxylic Acid Methyl Ester
CAS No.	141544-39-0
Molecular Formula	C44H50N4O9
Molecular Weight	778.90 g/mol
Synonyms	Methyl (3β,16α)-9,17-dihydroxy-21β-[(16E)-16,17-didehydro-17-methoxy-16-(methoxycarbonyl)-9-hydroxycorynan-10-yl]yohimban-16-carboxylate; 16α-Carbomethoxy-9,17α-dihydroxy-21β-[(16E)-16,17-didehydro-17-methoxy-16-(methoxycarbonyl)-9-hydroxycorynan-10-yl]yohimban; Alkaloid Yohimban Derivative; Corynan-Yohimban Hybrid Alkaloid Ester; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our (3β)-9,17α-Dihydroxy-21β-[[(16E)-16,17-Didehydro-17-Methoxy-16-(Methoxycarbonyl)-9-Hydroxycorynan]-10-Yl]Yohimban-16α-Carboxylic Acid Methyl Ester is produced and handled under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets exacting specifications for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting critical parameters such as assay, related substances, and residual solvents. We support compliance with ICH guidelines for stability and impurity profiling upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the Certificate of Analysis. The product is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep the container in a dry, cool, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.