Description

Tos-Peg2-Pht CAS NO 141282-26-0 is a specialized bifunctional chemical reagent featuring a tosyl (Tos) leaving group and a phthalimide (Pht) protecting group, linked by a polyethylene glycol (PEG2) spacer. This compound is a critical intermediate for the controlled synthesis and functionalization of complex molecules, enabling precise conjugation and modification strategies. It is primarily utilized by research scientists and process chemists in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as linker chemistry, polymer modification, and the development of prodrugs.

Application

• Pharmaceutical Linker Chemistry: Serves as a versatile building block for constructing cleavable linkers in antibody-drug conjugates (ADCs) and other targeted therapeutics.
• Polymer Functionalization: Used to introduce reactive tosylate groups or protected amine functionalities into PEG-based polymers and hydrogels for controlled cross-linking.
• Prodrug Synthesis: Acts as a key intermediate for attaching drug molecules via the PEG spacer, facilitating enhanced solubility and controlled release profiles.
• Bioconjugation: Enables the site-specific modification of peptides, proteins, and other biomolecules through sequential deprotection and coupling reactions.
• Material Science: Employed in the surface modification of nanoparticles and other nanomaterials to impart specific chemical reactivity or biocompatibility.
• Organic Synthesis Intermediate: Provides a protected amine precursor (after phthalimide removal) for the stepwise synthesis of complex organic molecules and dendrimers.

Basic Information

Item	Details
Product Name	Tos-Peg2-Pht
CAS No.	141282-26-0
Molecular Formula	C23H27NO8S
Molecular Weight	477.53 g/mol
Synonyms	2-[2-[2-(4-Methylbenzenesulfonyloxy)ethoxy]ethoxy]ethyl Isoindole-1,3-dione; 1,3-Dioxoisoindolin-2-yl-PEG2-OTs; Phthalimide-PEG2-tosylate; Tosyl-PEG2-phthalimide; N-(2-[2-(2-Tosyloxyethoxy)ethoxy]ethyl)phthalimide; PEG2-phthalimide tosylate; 2-(2-(2-(Tosyloxy)ethoxy)ethoxy)ethyl 1,3-dioxoisoindoline-2-carboxylate (common representation); Pht-NH-PEG2-OTs
EINECS	Contact for details

Quality Control

Our Tos-Peg2-Pht is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity assessment and NMR for structural confirmation, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container should be kept sealed in a desiccated environment to prevent moisture uptake, which can affect stability and reactivity. Allow the product to equilibrate to room temperature before opening to minimize condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.