Description

Anthranilyl-HIV Protease Substrate IV is a specialized fluorogenic peptide substrate designed for the sensitive and continuous assay of HIV-1 protease activity. This compound is critical for biochemical research and high-throughput screening (HTS) applications in antiviral drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and CROs (Contract Research Organizations) focused on developing and characterizing HIV protease inhibitors.

Application

• HIV-1 Protease Activity Assays: Primary substrate for fluorometric determination of protease kinetics and inhibition studies.
• Antiviral Drug Discovery: High-throughput screening (HTS) of compound libraries for potential HIV protease inhibitors.
• Enzyme Characterization: Used in biochemical research to study the catalytic mechanism and specificity of HIV protease.
• Diagnostic Development: A key component in developing in vitro diagnostic tests for monitoring protease function.
• Academic & Pharmaceutical Research: Essential tool for basic virology research and preclinical drug development programs targeting HIV.

Basic Information

Product Name	Anthranilyl-HIV Protease Substrate IV
CAS No.	141223-69-0
Molecular Formula	C43H56N8O11
Molecular Weight	861.0 g/mol
Synonyms	Abz-Thr-Ile-Nle-p-Nitro-Phe-Gln-Arg-NH2; MCA-Lys-Ala-Arg-Val-Leu*Phe-Glu-Ala-Nle-NH2 (where * denotes the cleavage site); HIV-1 Protease Substrate IV (Anthranilyl-labeled); Fluorogenic HIV Protease Substrate; 2-Aminobenzoyl-Thr-Ile-Nle-(p-NO2-Phe)-Gln-Arg-NH2; Abz-T-I-Nle-pNO2F-Q-R-NH2; HIV PR Substrate IV
EINECS	Contact for details

Quality Control

Our Anthranilyl-HIV Protease Substrate IV is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high performance in sensitive assay systems. Each lot is characterized by HPLC, mass spectrometry, and functional activity testing. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and performance data is provided with every shipment to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Functional Activity	Conforms to reference (Km provided on COA)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.