Description

(+/-)-18-Hydroxy-5Z,8Z,11Z,14Z,16E-Eicosapentaenoic Acid CAS NO 141110-17-0 is a specialized hydroxylated derivative of eicosapentaenoic acid (EPA), a key ω-3 fatty acid. This compound serves as a valuable biochemical tool and a potential synthetic intermediate due to its unique structure, which incorporates both hydroxyl and polyunsaturated functionalities. It is primarily utilized by researchers and developers in the pharmaceutical, nutraceutical, and life science sectors for studying lipid metabolism, inflammation pathways, and as a precursor for synthesizing bioactive lipid mediators.

Application

• Biochemical Research: Used as a reference standard or analytical reagent in lipidomics and metabolomics studies to investigate eicosanoid and specialized pro-resolving mediator (SPM) biosynthesis pathways.
• Pharmaceutical Development: Acts as a key synthetic intermediate or a lead compound in the research and development of novel anti-inflammatory and immunomodulatory agents.
• Nutraceutical Research: Employed in the study of advanced ω-3 formulations and the metabolic effects of hydroxylated fatty acids.
• Cell Signaling Studies: Utilized in vitro and in vivo to probe the role of oxidized lipid derivatives in cellular communication, inflammation resolution, and receptor interactions.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for the accurate quantification of related hydroxy fatty acids in complex biological matrices using techniques like LC-MS/MS.
• Organic Synthesis: Provides a chiral, polyunsaturated building block for the total synthesis of complex natural products and bioactive lipids.

Basic Information

Product Name	(+/-)-18-Hydroxy-5Z,8Z,11Z,14Z,16E-Eicosapentaenoic Acid
CAS No.	141110-17-0
Molecular Formula	C₂₀H₃₀O₃
Molecular Weight	318.45 g/mol
Synonyms	18-HEPE; (±)-18-Hydroxy-5Z,8Z,11Z,14Z,16E-eicosapentaenoic acid; 18-Hydroxy-EPA; 18-Hydroxyeicosapentaenoic acid; 18(R/S)-HEPE; 18-HETE (5,8,11,14,16); 18-Hydroxy-5,8,11,14,16-eicosapentaenoic acid; 18-Hydroxyicosa-5Z,8Z,11Z,14Z,16E-pentaenoic acid
EINECS	Contact for details

Quality Control

Our (+/-)-18-Hydroxy-5Z,8Z,11Z,14Z,16E-Eicosapentaenoic Acid is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with every shipment to support your research and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term storage, keep at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	Colorless to pale yellow oil or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Assay (GC or Titration)	≥90% (by weight)
Solubility	Soluble in ethanol, DMSO, and organic solvents

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.