Description

Calcifediol-D3 is a high-purity, deuterated analog of calcifediol, a key intermediate in the vitamin D metabolic pathway. This compound is essential for research and development in pharmaceutical and nutraceutical applications, particularly for metabolic studies and the synthesis of labeled vitamin D analogs. It is primarily utilized by research institutions, pharmaceutical R&D departments, and advanced manufacturers developing targeted therapies and diagnostic tools related to calcium homeostasis and bone health.

Application

• Pharmaceutical Reference Standard: Used as an internal standard or calibrant in quantitative analytical methods like LC-MS/MS for drug metabolism and pharmacokinetic (DMPK) studies.
• Deuterated Tracer in Research: Serves as a stable isotope-labeled tracer in metabolic pathway research to study the bioconversion of vitamin D and its metabolites.
• Advanced Synthesis Intermediate: A critical building block for the synthesis of novel, deuterium-labeled vitamin D receptor (VDR) modulators and other high-value pharmaceutical compounds.
• Clinical Research Material: Employed in the development and validation of clinical assays for measuring 25-hydroxyvitamin D levels and related metabolites with high specificity.
• Nutraceutical R&D: Used in stability studies and metabolic research for next-generation vitamin D supplements and fortified products.

Basic Information

Product Name	Calcifediol-D3
CAS No.	140710-94-7
Molecular Formula	C27H41D3O2
Molecular Weight	403.64 g/mol
Synonyms	25-Hydroxyvitamin D3-26,26,26-d3; 25-Hydroxycholecalciferol-d3; (3β,5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-3,25-diol-26,26,26-d3; 25-Hydroxy VD3-d3; 25(OH)D3-d3; 25-Hydroxyvitamin D3 (deuterated); 25-Hydroxy VD3 (26,26,26-d3)
EINECS	Contact for details

Quality Control

Our Calcifediol-D3 is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and isotopic enrichment, NMR for structural confirmation, and MS for identity verification. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to prevent oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chemical Purity	≥ 95%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.