Description

2,5-Dioxo-1-Pyrrolidinyl 2-Propynoate is a highly reactive, heterobifunctional cross-linking agent and activated ester. This compound matters for its ability to efficiently introduce alkyne groups into target molecules, enabling subsequent click chemistry reactions such as the copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is primarily needed by researchers and manufacturers in the pharmaceutical, bioconjugation, and advanced materials sectors for synthesizing probes, polymers, and drug conjugates.

Application

• Key reagent for bioconjugation and labeling of proteins, peptides, and antibodies.
• Introduction of alkyne handles for subsequent click chemistry applications in drug discovery.
• Synthesis of functionalized polymers and dendrimers for advanced material science.
• Preparation of activity-based probes (ABPs) for proteomics and enzyme studies.
• Cross-linking agent in the development of hydrogel networks and biomaterials.
• Intermediate in the synthesis of specialized pharmaceutical intermediates and active pharmaceutical ingredients (APIs).

Basic Information

Product Name	2,5-Dioxo-1-Pyrrolidinyl 2-Propynoate
CAS No.	140681-41-0
Molecular Formula	C7H5NO4
Molecular Weight	167.12 g/mol
Synonyms	Propargyl N-succinimidyl carbonate; NSC 332007; 2,5-Dioxopyrrolidin-1-yl propiolate; 1-(Propioloyloxy)-2,5-pyrrolidinedione; Propiolic acid N-hydroxysuccinimide ester; N-Hydroxysuccinimide propiolate; NHS-propiolate; Succinimidyl propiolate
EINECS	Contact for details

Quality Control

Our 2,5-Dioxo-1-Pyrrolidinyl 2-Propynoate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC and NMR, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.