Description

11-Hydroxyyohimbine is a significant alkaloid derivative, primarily recognized for its role as a key intermediate in pharmaceutical research and development. This compound is valued for its structural relationship to yohimbine, offering a critical building block for synthesizing novel bioactive molecules and reference standards. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors who require high-purity intermediates for drug discovery and analytical applications.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of specialized alkaloid-based active pharmaceutical ingredients (APIs) and investigational new drugs.
• Biochemical Research: Used as a reference standard and tool compound in pharmacological studies targeting adrenergic and other receptor systems.
• Analytical Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories (HPLC, LC-MS).
• Fine Chemical Synthesis: Employed in organic synthesis to create novel chemical entities for screening libraries and structure-activity relationship (SAR) studies.
• Nutraceutical R&D: Investigated as a potential intermediate for the development of specialized dietary supplements and natural product derivatives.

Basic Information

Product Name	11-Hydroxyyohimbine
CAS No.	140405-13-6
Molecular Formula	C21H26N2O4
Molecular Weight	370.45 g/mol
Synonyms	11α-Hydroxyyohimbine; 11-Hydroxy-17α-hydroxyyohimban-16α-carboxylic acid methyl ester; 11-Hydroxyyohimban-16α-carboxylic acid, methyl ester, (16α,17α)-; Yohimbine, 11-hydroxy-; 11-Hydroxyyohimbine hydrochloride (salt form); Rauwolscine, 11-hydroxy-; 11-OH-Yohimbine
EINECS	Contact for details

Quality Control

Our 11-Hydroxyyohimbine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR spectroscopy, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP intermediate requirements. Specifications are aligned with industry standards for high-purity fine chemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and may be hygroscopic (moisture-sensitive); therefore, the container should be kept tightly sealed in a dry environment. For long-term storage, consider conditions under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.2%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.