Description

(+/-)-Epibatidine CAS NO 140111-52-0 is a potent nicotinic acetylcholine receptor (nAChR) agonist, originally isolated from the skin of the Ecuadorian poison frog *Epipedobates anthonyi*. This compound is of significant interest in neuroscience research due to its high affinity and unique pharmacological profile. It serves as a critical research tool for studying pain pathways, receptor subtypes, and the development of novel analgesic agents. Key users include pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on neuropharmacology and drug discovery.

Application

• Neuroscience Research: As a high-affinity ligand for studying the structure and function of neuronal nicotinic acetylcholine receptors (nAChRs).
• Pharmacological Studies: Used in *in vitro* and *in vivo* models to investigate pain perception, analgesia, and receptor signaling pathways.
• Drug Discovery: A key reference compound and chemical scaffold for the design and development of new non-opioid analgesic drugs.
• Biochemical Assays: Employed in receptor binding assays, functional studies, and high-throughput screening (HTS) campaigns.
• Toxicology Research: For studying the effects of potent neuroactive alkaloids and their mechanisms of action.
• Chemical Synthesis: Serves as a sophisticated intermediate or target molecule in advanced organic and medicinal chemistry synthesis.

Basic Information

Product Name	(+/-)-Epibatidine
CAS No.	140111-52-0
Molecular Formula	C11H13ClN2
Molecular Weight	208.69 g/mol
Synonyms	Epibatidine (racemic); (±)-Epibatidine; exo-2-(6-Chloro-3-pyridyl)-7-azabicyclo[2.2.1]heptane; 2-(6-Chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane; ABT-418 (related analog); ANR 094; NSC 324666
EINECS	Contact for details

Quality Control

Our (+/-)-Epibatidine is produced and handled under strict quality management protocols to ensure the high purity and consistency required for sensitive research applications. Each batch undergoes comprehensive analytical testing, including HPLC for purity determination and spectroscopic methods for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and relevant physicochemical parameters to support your research and regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.