Description

1-((2-Chloroethoxy)Methyl)-5-Fluorouracil is a specialized fluorinated pyrimidine derivative, a key intermediate in advanced pharmaceutical synthesis. This compound matters for its role in developing novel chemotherapeutic agents and targeted drug delivery systems, offering researchers a pathway to create more effective and selective treatments. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on oncology research and prodrug development.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel antimetabolite chemotherapeutic agents and prodrugs designed for targeted cancer therapy.
• Oncology Research: Used in academic and industrial R&D for studying structure-activity relationships (SAR) of fluorouracil derivatives to improve efficacy and reduce side effects.
• Prodrug Development: Serves as a precursor for creating prodrugs with enhanced bioavailability and tumor-specific activation, leveraging the 2-chloroethoxy moiety as a potential cleavable linker.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for constructing complex molecules with potential biological activity beyond oncology.
• Biochemical Tool Compound: Utilized in biochemical assays to investigate mechanisms of thymidylate synthase inhibition and DNA/RNA incorporation.

Basic Information

Product Name	1-((2-Chloroethoxy)Methyl)-5-Fluorouracil
CAS No.	139593-08-1
Molecular Formula	C8H10ClFN2O3
Molecular Weight	236.63 g/mol
Synonyms	5-Fluoro-1-[(2-chloroethoxy)methyl]uracil; 1-[(2-Chloroethoxy)methyl]-5-fluoropyrimidine-2,4(1H,3H)-dione; 5-Fluorouracil, 1-[(2-chloroethoxy)methyl]-; N1-(2-Chloroethoxymethyl)-5-fluorouracil; 1-(2-Chloroethoxymethyl)-5-fluorouracil; CEM-FU; 5-FU CEM derivative
EINECS	Contact for details

Quality Control

Our 1-((2-Chloroethoxy)Methyl)-5-Fluorouracil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and pharmaceutical intermediate use. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using a desiccant.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 1.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.