Description

10-Ethyl-5-Methyl-5,10-Dideazaaminopterin is a synthetic analog of aminopterin, belonging to the class of folate antagonists. This compound is of significant interest in pharmaceutical research and development due to its potential as a targeted therapeutic agent. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel anticancer and anti-inflammatory drugs, where it serves as a critical intermediate or active pharmaceutical ingredient (API) in preclinical studies.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the synthesis and study of novel chemotherapeutic agents.
• Anticancer Drug Discovery: Investigation of its mechanism as a dihydrofolate reductase (DHFR) inhibitor for targeted cancer therapies.
• Biochemical Research: Used as a tool compound to study folate metabolism and its role in cell proliferation.
• Academic Research: Serves as a standard in university and institutional labs for metabolic pathway studies and enzyme inhibition assays.
• Preclinical Development: Evaluation of pharmacokinetics, pharmacodynamics, and toxicology profiles for potential new chemical entities (NCEs).

Basic Information

Product Name	10-Ethyl-5-Methyl-5,10-Dideazaaminopterin
CAS No.	139504-90-8
Molecular Formula	C₂₁H₂₅N₇O₄
Molecular Weight	439.47 g/mol
Synonyms	10-Ethyl-5-methyl-5,10-dideazaaminopterin; 5,10-Dideaza-10-ethyl-5-methylaminopterin; Ethylmethyl Dideazaaminopterin; Dideazaaminopterin analog; LY-309887 analog; Antifolate analog; NSC-755130 (related); Pharmaceutical Intermediate 139504-90-8
EINECS	Contact for details

Quality Control

Our 10-Ethyl-5-Methyl-5,10-Dideazaaminopterin is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency, suitable for research and development purposes. We adhere to current Good Manufacturing Practices (cGMP) where applicable for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.