Description

1-o-(6-Carboxylhexyl)Glycero-3-Phosphoserine is a specialized synthetic phospholipid derivative, a key building block in advanced lipid research and formulation. This compound is crucial for the development of novel drug delivery systems, particularly liposomes and lipid nanoparticles, due to its functional carboxyl group which enables targeted conjugation. It is primarily used by pharmaceutical R&D teams, advanced material scientists, and manufacturers of diagnostic reagents seeking to create next-generation, functionalized lipid-based carriers.

Application

• Liposome & Lipid Nanoparticle (LNP) Formulation: A critical functional excipient for constructing pH-sensitive or ligand-targeted drug delivery vehicles for mRNA, siRNA, and small molecule therapeutics.
• Bioconjugation & Surface Modification: The terminal carboxyl group allows for covalent attachment of targeting ligands (e.g., antibodies, peptides) or PEG chains to enhance specificity and circulation time.
• Biomimetic Membrane Research: Used in model membrane systems to study the effects of anionic, functionalized phospholipids on membrane curvature, fusion, and protein interactions.
• Diagnostic Reagent Development: Serves as a foundational component in the synthesis of fluorescent or chemically tagged phospholipid probes for cellular imaging and assays.
• Cosmetic Actives Delivery: Employed in high-end cosmetic formulations to create nanocarriers for improved skin penetration and stability of active ingredients.

Basic Information

Item	Detail
Product Name	1-o-(6-Carboxylhexyl)Glycero-3-Phosphoserine
CAS No.	139239-73-9
Molecular Formula	C13H26NO10P
Molecular Weight	387.32 g/mol
Synonyms	1-(6-Carboxyhexyl)-2-hydroxy-3-(phosphonooxy)propyl hydrogen phosphate; 6-Carboxyhexyl Phosphatidylserine analog; PS-C6-COOH; Anionic functionalized phosphatidylserine; 1-O-(6-Carboxyhexyl)-sn-glycero-3-phospho-L-serine; Carboxylated phosphatidylserine; Phosphatidylserine hexanoic acid derivative
EINECS	Contact for details

Quality Control

Every batch of 1-o-(6-Carboxylhexyl)Glycero-3-Phosphoserine is manufactured under strict quality management systems. We provide comprehensive analytical data to support its use in GMP and research applications, including HPLC purity, structural confirmation by NMR and MS, and critical impurity profiling. Certificates of Analysis (COA) with full traceability are available for all shipments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive). For long-term storage, keep under an inert atmosphere (argon or nitrogen) to ensure stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.