Description

Dorzolamide CAS NO 139066-77-6 is a potent and selective carbonic anhydrase inhibitor, a key active pharmaceutical ingredient (API) in the treatment of elevated intraocular pressure. This compound is critical for the formulation of ophthalmic solutions used to manage conditions such as glaucoma and ocular hypertension. It is an essential raw material for pharmaceutical manufacturers, research institutions, and contract development and production organizations (CDMOs) focused on ophthalmic therapeutics.

Application

• Primary Active Pharmaceutical Ingredient (API) in topical ophthalmic solutions for glaucoma.
• Key component in combination drug therapies for enhanced intraocular pressure reduction.
• Reference standard for analytical method development and quality control in pharmaceutical laboratories.
• Critical raw material for research into novel ophthalmic drug delivery systems.
• Intermediate in the synthesis of more complex carbonic anhydrase inhibitors for research purposes.
• Used in preclinical and clinical studies investigating new therapeutic applications.

Basic Information

Product Name	Dorzolamide
CAS No.	139066-77-6
Molecular Formula	C10H16N2O4S3
Molecular Weight	324.39 g/mol
Synonyms	(4S,6S)-4-(Ethylamino)-5,6-dihydro-6-methyl-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide; L-671,152; MK-0507; Trusopt (Brand Name); Dorzolamide Hydrochloride (Salt Form); Dorzolamide HCl; (S,S)-Dorzolamide; 4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, (4S,6S)-
EINECS	Contact for details

Quality Control

Our Dorzolamide is manufactured under strict quality management systems to meet the rigorous standards required for pharmaceutical applications. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via validated methods such as HPLC. Certificates of Analysis (COA) are provided to ensure traceability and compliance with customer specifications and relevant pharmacopeial guidelines (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.