Description

H-Pro-Arg-βna · Hcl CAS NO 138914-35-9 is a protected dipeptide derivative, specifically the hydrochloride salt of H-Pro-Arg-βna. This compound serves as a crucial synthetic intermediate and biochemical tool, valued for its role in peptide synthesis and protease research. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors for developing novel therapeutic agents and conducting enzymatic studies.

Application

• Pharmaceutical Intermediate: Key building block in the solid-phase and solution-phase synthesis of complex peptide-based drugs and bioactive peptides.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic assays to study the activity and specificity of proteases, particularly trypsin-like enzymes.
• Protease Inhibitor Development: Serves as a core structure for designing and screening potential inhibitors for diseases where protease activity is dysregulated.
• Chemical Biology Probes: Employed in the development of activity-based probes (ABPs) to label and detect active proteases in complex biological systems.
• Academic & Industrial R&D: Fundamental reagent in university and corporate research laboratories for investigating peptide metabolism and enzyme kinetics.

Basic Information

Product Name	H-Pro-Arg-βna · HCl
CAS No.	138914-35-9
Molecular Formula	C19H28ClN7O4
Molecular Weight	453.92 g/mol
Synonyms	H-Pro-Arg-βNA hydrochloride; L-Prolyl-L-arginine 4-nitroanilide hydrochloride; H-Pro-Arg-pNA · HCl; Pro-Arg-p-Nitroanilide hydrochloride; Boc-Pro-Arg-4-nitroanilide HCl (common precursor); Suc-Pro-Arg-AMC · HCl (related fluorogenic substrate); Protease Substrate H-Pro-Arg-βna; Trypsin Chromogenic Substrate Derivative
EINECS	Contact for details

Quality Control

Our H-Pro-Arg-βna · HCl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or cGMP guidelines for non-active raw materials.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.