Description

(1-Palmitoyl-2-Nbd-Aminododecanoyl)Phosphatidylserine is a specialized, fluorescently labeled phospholipid derivative, crucial for advanced biochemical and biophysical research. Its core value lies in enabling the sensitive detection and real-time tracking of phosphatidylserine dynamics in complex biological systems. This compound is essential for researchers and developers in the fields of membrane biology, apoptosis (cell death) studies, and drug discovery, particularly for investigating lipid-protein interactions and cellular signaling pathways.

Application

• Biomembrane Research: As a fluorescent probe for studying phosphatidylserine distribution, flip-flop, and asymmetry in lipid bilayers and model membranes.
• Apoptosis Detection: A critical tool for the sensitive and quantitative detection of phosphatidylserine externalization, a hallmark of early-stage programmed cell death.
• Lipid-Protein Interaction Studies: Used to investigate the binding and functional modulation of proteins (e.g., annexins, coagulation factors) by phosphatidylserine.
• Drug Discovery & Screening: Employed in high-throughput assays to identify compounds that modulate phosphatidylserine-related pathways, such as in cancer or neurodegenerative diseases.
• Vesicle & Liposome Labeling: Incorporated into liposomal formulations to trace cellular uptake, biodistribution, and stability of drug delivery systems.
• Neuroscience Research: Applied in studies of synaptic vesicle fusion, neurotransmitter release, and other membrane fusion events where phosphatidylserine plays a role.

Basic Information

Product Name	(1-Palmitoyl-2-Nbd-Aminododecanoyl)Phosphatidylserine
CAS No.	138898-75-6
Molecular Formula	C₄₉H₈₀N₄O₁₃P
Molecular Weight	964.14 g/mol
Synonyms	NBD-PS; 1-Palmitoyl-2-[12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl]-sn-glycero-3-phosphoserine; Fluorescent Phosphatidylserine; NBD Labeled Phosphatidylserine; PS-NBD; 1-Palmitoyl-2-(NBD-aminododecanoyl)-sn-glycero-3-phosphoserine; NBD-PtdSer
EINECS	Contact for details

Quality Control

Our (1-Palmitoyl-2-Nbd-Aminododecanoyl)Phosphatidylserine is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency required for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, mass spectrometry for identity confirmation, and fluorescence spectroscopy for performance validation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid or film
Identification (Mass Spec)	Conforms to structure
Purity (HPLC)	≥ 95%
Extinction Coefficient (ε)	~21,000 cm⁻¹M⁻¹ (in methanol)
Excitation/Emission Maxima	~465 nm / ~535 nm (in lipid membranes)
Solubility	Chloroform, Methanol, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.