Description

Brinzolamide CAS NO 138890-62-7 is a potent and selective carbonic anhydrase inhibitor used primarily in ophthalmic formulations. This active pharmaceutical ingredient (API) is critical for the effective management of elevated intraocular pressure, a key factor in conditions like glaucoma. Pharmaceutical manufacturers and research institutions rely on high-purity brinzolamide for the development and production of sterile eye drops and other advanced ocular therapeutics.

Application

• Primary Active Ingredient in Ophthalmic Solutions: Formulated into sterile eye drops (suspensions) for the treatment of open-angle glaucoma and ocular hypertension.
• Pharmaceutical Research & Development (R&D): Used in preclinical and clinical studies for developing new topical carbonic anhydrase inhibitors.
• Drug Product Manufacturing: Serves as the core API in Good Manufacturing Practice (GMP) compliant production lines for branded and generic medications.
• Combination Therapies: Utilized in fixed-dose combination products with other intraocular pressure-lowering agents like β-blockers.
• Analytical Reference Standard: Provides a high-purity benchmark for quality control laboratories performing HPLC, assay, and impurity profiling.

Basic Information

Product Name	Brinzolamide
CAS No.	138890-62-7
Molecular Formula	C12H21N3O5S3
Molecular Weight	383.51 g/mol
Synonyms	(R)-(+)-4-Ethylamino-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-Dioxide; AL-4862; Azopt (Brand Name); 1,1-Dioxo-4-ethylamino-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e]-1,2-thiazine-6-sulfonamide; (4R)-4-(Ethylamino)-3,4-dihydro-2-(3-methoxypropyl)-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-Dioxide
EINECS	Contact for details

Quality Control

Our Brinzolamide is manufactured under strict quality systems to meet the rigorous standards of the pharmaceutical industry. Each batch is tested against comprehensive specifications, including identity, purity, assay, and impurity profiles (including related substances and residual solvents) using validated methods such as HPLC, IR spectroscopy, and titration. A Certificate of Analysis (COA) documenting full compliance is provided with every shipment. We support development and commercial needs with material suitable for use under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere packaging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.