Description

(S)-3'-Hydroxy-n-Methylcoclaurine Hydrochloride is a high-purity, chiral benzylisoquinoline alkaloid derivative supplied as its hydrochloride salt. This compound serves as a critical advanced pharmaceutical intermediate and a valuable reference standard for research and development. It is primarily utilized by professionals in the pharmaceutical, biotechnology, and fine chemical synthesis sectors for the development of novel therapeutics and analytical method validation.

Application

• Pharmaceutical Intermediate: Key chiral building block in the synthesis of complex alkaloids and potential active pharmaceutical ingredients (APIs).
• Biochemical Research: Reference standard and precursor for studying biosynthetic pathways of isoquinoline alkaloids in plants.
• Medicinal Chemistry: Valuable scaffold for drug discovery programs targeting neurological and cardiovascular receptors.
• Analytical Standard: High-purity material for use as a calibration standard in HPLC, LC-MS, and other chromatographic methods for quality control.
• Process Development: Used in route scouting and optimization for the commercial-scale production of specialty fine chemicals.

Basic Information

Product Name	(S)-3'-Hydroxy-n-Methylcoclaurine Hydrochloride
CAS No.	138644-99-2
Molecular Formula	C19H24NO4 • HCl
Molecular Weight	365.86 g/mol (Free base: 330.40 g/mol)
Synonyms	(S)-3'-Hydroxy-N-methylcoclaurine HCl; (1S)-1,2,3,4-Tetrahydro-6-hydroxy-1-[(4-hydroxy-3-methoxyphenyl)methyl]-7-methoxy-2-methylisoquinolin-8-ol hydrochloride; N-Methylcoclaurine-3'-ol hydrochloride; (S)-N-Methylcoclaurinol hydrochloride; Reticuline derivative; Isoquinoline alkaloid hydrochloride
EINECS	Contact for details

Quality Control

Our (S)-3'-Hydroxy-n-Methylcoclaurine Hydrochloride is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for research and pharmaceutical use. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.