Description

1 2-Dioleoyl-Sn-Glycero-3-Phosphoethanol (CAS NO 137819-86-4) is a high-purity synthetic phospholipid, specifically a phosphatidylethanolamine (PE) with two oleoyl chains. This compound is a critical building block in advanced formulation science, enabling the creation of stable, biocompatible lipid-based delivery systems. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and nutraceutical industries developing next-generation therapeutics and supplements.

Application

• Liposome and Nanoparticle Formulation: A key component for constructing the lipid bilayer in drug delivery vesicles for targeted cancer therapies, mRNA vaccines, and gene delivery systems.
• Biomimetic Membrane Research: Used to create model cell membranes for studying protein-lipid interactions, membrane fusion, and cellular signaling pathways.
• Diagnostic Reagent Preparation: Serves as a substrate or coating material in diagnostic assays and biosensors to improve specificity and sensitivity.
• Cosmetic and Dermal Delivery: Incorporated into topical formulations like nanosomes and transfersomes to enhance skin penetration and stability of active ingredients.
• Cell Culture and Transfection: Used as a supplement in serum-free media or as a component of transfection reagents to improve cell viability and nucleic acid uptake.
• Structural Biology: Essential for crystallizing membrane proteins to facilitate 3D structure determination via techniques like X-ray crystallography.

Basic Information

Item	Detail
Product Name	1 2-Dioleoyl-Sn-Glycero-3-Phosphoethanol
CAS No.	137819-86-4
Molecular Formula	C43H80NO8P
Molecular Weight	788.07 g/mol
Synonyms	DOPE; 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine; Dioleoylphosphatidylethanolamine; (2,3-Dioleoyloxy-propyl)-phosphonoethanolamine; (9Z,9'Z)-N-[(2-Hydroxyethoxy)hydroxyphosphinyl]-O,O'-bis(9-octadecenoyl)-L-serinamide; 1,2-Di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; L-α-Phosphatidylethanolamine-dioleoyl
EINECS	Contact for details

Quality Control

Our 1 2-Dioleoyl-Sn-Glycero-3-Phosphoethanol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and cGMP-grade applications. Certificates of Analysis (COA) with full traceability are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and hydrolysis. The material is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Lyso-Impurity (HPLC)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines
Water Content (KF)	≤ 1.0%
Peroxide Value	≤ 3.0 meq/kg
Phase Transition Temperature (DSC)	Approx. -16°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.