Description

4,8-Dihydro-4-Hydroxy-8-Oxo-2'-Deoxyguanosine is a modified nucleoside derivative of deoxyguanosine, representing a specific oxidative lesion of DNA. This compound is of significant interest in biochemical and pharmaceutical research due to its role as a biomarker for oxidative stress and DNA damage. It is primarily utilized by researchers and manufacturers in the fields of analytical chemistry, molecular biology, and drug discovery, where precise study of nucleic acid modifications is critical.

Application

• Biomarker Research: Used as a standard reference material for the detection and quantification of oxidative DNA damage in biological samples.
• Analytical Chemistry: Serves as a critical analytical standard in HPLC, LC-MS, and other chromatographic methods for method development and validation.
• Pharmaceutical Development: Employed in studies investigating the mechanisms of mutagenesis, carcinogenesis, and the efficacy of antioxidant therapies.
• Academic Research: Essential for fundamental research in biochemistry and molecular biology focused on DNA repair pathways and genomic stability.
• Diagnostic Kit Manufacturing: Can be incorporated into kits designed to measure oxidative stress levels for clinical or research diagnostics.
• Toxicology Studies: Applied in assessing the genotoxic effects of environmental toxins, radiation, and pharmaceutical compounds.

Basic Information

Product Name	4,8-Dihydro-4-Hydroxy-8-Oxo-2'-Deoxyguanosine
CAS No.	137608-89-0
Molecular Formula	C10H13N5O6
Molecular Weight	299.24 g/mol
Synonyms	4,8-dihydro-4-hydroxy-8-oxo-2'-deoxyguanosine; 4-OH-8-oxo-dG; 4-Hydroxy-8-oxo-2'-deoxyguanosine; 8-Oxo-4-hydroxy-2'-deoxyguanosine; 4,8-Dihydro-8-oxo-2'-deoxyguanosine; 4-OH-8-oxodG; Oxidative guanine lesion; 2'-Deoxy-4,8-dihydro-4-hydroxy-8-oxoguanosine
EINECS	Contact for details

Quality Control

Our 4,8-Dihydro-4-Hydroxy-8-Oxo-2'-Deoxyguanosine is produced and handled under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis and spectroscopic identification. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.