Description

Glutathione Maleimide CAS NO 137593-43-2 is a high-purity, bifunctional chemical reagent designed for site-specific bioconjugation. This compound is essential for creating stable thioether linkages, enabling the precise attachment of biomolecules such as peptides, proteins, and antibodies to various carriers, probes, or surfaces. It is a critical tool for researchers and manufacturers in the fields of biopharmaceutical development, diagnostic assay production, and advanced life science research.

Application

• Antibody-Drug Conjugate (ADC) Development: Site-specific conjugation of cytotoxic payloads to monoclonal antibodies for targeted cancer therapies.
• Protein and Peptide Labeling: Covalent attachment of fluorescent dyes, enzymes, or other reporter molecules for imaging, detection, and diagnostic applications.
• Surface Functionalization: Immobilization of biomolecules onto biosensor chips, microarrays, or nanoparticle surfaces to create bioactive interfaces.
• Crosslinking and Stabilization: Creating stable crosslinks within or between protein structures for structural studies or to enhance stability.
• Polymer Conjugation: Modification of polymers (e.g., PEG) with thiol-reactive groups for creating advanced drug delivery systems.
• Diagnostic Reagent Synthesis: Production of key components for immunoassays (ELISA, lateral flow tests) and other clinical diagnostics.

Basic Information

Product Name	Glutathione Maleimide
CAS No.	137593-43-2
Molecular Formula	C13H19N4O8S
Molecular Weight	391.38 g/mol
Synonyms	N-(2-{[(4S)-4-Amino-4-carboxybutanoyl]amino}-1-{[(1S)-2-[(4S)-4-amino-4-carboxybutanamido]-1-(carboxymethylcarbamoyl)ethyl]carbamoyl}ethyl)-2,5-dioxo-2,5-dihydro-1H-pyrrole-1-carboxamide; L-Glutathione Maleimide; γ-Glu-Cys-Gly Maleimide; GSH Maleimide; Reduced Glutathione Maleimide; Maleimido-Glutathione; Thiol-Reactive Glutathione
EINECS	Contact for details

Quality Control

Our Glutathione Maleimide is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for bioconjugation research and cGMP-grade manufacturing. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; Sparingly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.