Description

5-Azido-UDP-Glucuronic Acid is a chemically modified nucleotide sugar derivative, specifically engineered for advanced biochemical research and development. This compound serves as a critical tool for studying and manipulating glucuronidation pathways, a vital phase II detoxification process in biological systems. It is primarily utilized by researchers and scientists in the fields of glycobiology, enzymology, and medicinal chemistry for applications such as enzyme mechanism studies, inhibitor screening, and the synthesis of novel glycoconjugates.

Application

• Enzymology Research: A key substrate analog for investigating the activity, kinetics, and inhibition of UDP-glucuronosyltransferase (UGT) enzymes.
• Glycoconjugate Synthesis: Used as a building block in chemoenzymatic or chemical synthesis to create azide-labeled glycans or glycoconjugates for downstream bioorthogonal labeling (e.g., click chemistry).
• Metabolic Pathway Studies: Enables the probing of glucuronidation pathways in drug metabolism and xenobiotic detoxification studies.
• Probe Development: Acts as a precursor for developing activity-based probes (ABPs) to visualize and quantify UGT enzyme activity in complex biological samples.
• High-Throughput Screening (HTS): Employed in assay development for screening potential modulators or inhibitors of glucuronidation processes in drug discovery.
• Biochemical Tool: Useful for studying the substrate specificity and catalytic mechanisms of glycosyltransferases involved in polysaccharide biosynthesis.

Basic Information

Product Name	5-Azido-UDP-Glucuronic Acid
CAS No.	137528-00-8
Molecular Formula	C15H20N5O18P2
Molecular Weight	620.30 g/mol
Synonyms	5-Azido-UDP-GlcA; UDP-5-Azido-Glucuronic Acid; 5-N3-UDP-GlcA; Uridine 5'-[trihydrogen diphosphate], 5'-5'-ester with 5-azido-5-deoxy-D-glucopyranuronic acid; 5-Azido-5-deoxyuridine diphosphate glucuronic acid; Azido-UDP-glucuronate; 5-Azido-UDP-α-D-glucuronic acid
EINECS	Contact for details

Quality Control

Our 5-Azido-UDP-Glucuronic Acid is produced under stringent quality protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC and NMR, are validated to provide reliable specifications for the research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, consider desiccation and storage under an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.