Description

5,10-Ethano-5,10-Dideazaaminopterin is a synthetic folate analog and a potent inhibitor of dihydrofolate reductase (DHFR), representing a significant advancement in antifolate chemistry. This compound is valued for its enhanced metabolic stability and targeted inhibitory activity, making it a critical intermediate and reference standard in pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology drug discovery, enzyme inhibition studies, and the development of novel chemotherapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel antifolate chemotherapeutic agents.
• Biochemical Research: Used as a potent and specific inhibitor of dihydrofolate reductase (DHFR) in enzymatic and cellular assays.
• Oncology Drug Discovery: Acts as a reference compound for evaluating the efficacy and mechanism of new anticancer candidates targeting folate metabolism.
• Academic Research: Employed in universities and research institutes for studying folate pathways, enzyme kinetics, and resistance mechanisms.
• Reference Standard: Utilized in analytical laboratories for method development, validation, and quality control of related pharmaceutical substances.

Basic Information

Product Name	5,10-Ethano-5,10-Dideazaaminopterin
CAS No.	137465-07-7
Molecular Formula	C20H23N7O5
Molecular Weight	441.44 g/mol
Synonyms	5,10-Ethano-5,10-dideazaaminopterin; DDATHF; Lometrexol; 5,10-Dideaza-5,6,7,8-tetrahydroaminopterin; 5,10-Dideazatetrahydroaminopterin; 5,10-Dideaza-5,6,7,8-tetrahydrofolic acid; (6R)-5,10-Dideaza-5,6,7,8-tetrahydrofolic acid; GW1843
EINECS	Contact for details

Quality Control

Every batch of 5,10-Ethano-5,10-Dideazaaminopterin is manufactured and tested under strict quality management systems. We ensure high purity and batch-to-batch consistency through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with each shipment to support your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.