Description

Pro-Calcitriol Ptad Adduct is a chemically modified derivative of calcitriol, designed for enhanced stability and specific reactivity in advanced synthesis. This compound is critical for researchers and manufacturers requiring a high-purity, reliable intermediate for the production of vitamin D analogs and related pharmaceutical actives. It serves as a key building block in the development of therapeutic agents targeting bone metabolism, psoriasis, and certain cancers, making it essential for pharmaceutical R&D and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel vitamin D receptor (VDR) agonists and antagonists for drug development.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Employed in metabolic pathway studies and receptor binding assays to investigate the mechanisms of calcitriol and its analogs.
• Fine Chemical Synthesis: Serves as a specialized intermediate for creating labeled compounds (e.g., deuterated, fluorinated) for tracer studies.
• Process Chemistry: Utilized in scaling up the production of target molecules in pilot plants and commercial manufacturing.

Basic Information

Product Name	Pro-Calcitriol Ptad Adduct
CAS No.	137342-95-1
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	1α,25-Dihydroxyvitamin D3 3-(Phenyltriazoline)dione Adduct; Calcitriol-PTAD Adduct; PTAD Derivative of Calcitriol; 1,25-(OH)2D3-PTAD; Vitamin D3 Metabolite Adduct; (5Z,7E)-9,10-Secocholesta-5,7,10(19)-triene-1,3,25-triol PTAD Adduct
EINECS	Contact for details

Quality Control

Our Pro-Calcitriol Ptad Adduct is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a desiccated environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.