Description

Pemetrexed CAS NO 137281-23-3 is a synthetic pyrrolopyrimidine-based antimetabolite, functioning as a potent inhibitor of multiple folate-dependent enzymes. This compound is of critical importance in the development and manufacturing of targeted chemotherapeutic agents. It is primarily required by pharmaceutical manufacturers and research institutions engaged in oncology drug development and production.

Application

• Active Pharmaceutical Ingredient (API) in the manufacture of chemotherapeutic drugs for non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma.
• Reference Standard for quality control and analytical method development in pharmaceutical laboratories.
• Research Chemical for preclinical and clinical studies investigating novel cancer treatment regimens and combination therapies.
• Intermediate in the synthesis of more complex pharmaceutical compounds and prodrugs.
• Biochemical Research tool for studying folate metabolism, enzyme inhibition, and cellular proliferation pathways.

Basic Information

Product Name	Pemetrexed
CAS No.	137281-23-3
Molecular Formula	C20H21N5O6
Molecular Weight	427.41 g/mol
Synonyms	Pemetrexed Disodium; LY231514; Alimta (Brand Name); N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid; (2S)-2-[[4-[2-(2-Amino-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]pentanedioic Acid; MTA; Multitargeted Antifolate
EINECS	Contact for details

Quality Control

Our Pemetrexed is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity pharmaceutical standards, including identity, potency, and impurity profile verification. Certificates of Analysis (COA) detailing specifications such as assay, related substances, residual solvents, and microbiological limits are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Complies with Ph. Eur. 2.6.12/2.6.13

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.