Description

2-Deoxy-2-[(R)-3-[(R)-3-Hydroxytetradecanoyloxy]Tetradecanoylamino]-3-o-[(R)-3-(Tetradecanoyloxy)Tetradecanoyl]-α-D-Glucopyranose 4-Phosphoric Acid is a complex, high-purity synthetic lipid A derivative, a key structural component of bacterial endotoxins. This compound is of critical importance in immunological research and pharmaceutical development, serving as a precise tool for studying innate immune responses and Toll-like receptor 4 (TLR4) signaling pathways. It is primarily needed by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on vaccine adjuvants, immunotherapies, and sepsis research.

Application

• Immunological Research: As a defined, synthetic ligand for studying TLR4/MD-2 receptor activation and downstream cytokine production.
• Vaccine Adjuvant Development: A critical reference standard and active component in the research of next-generation vaccine adjuvants to enhance immune response.
• Sepsis and Inflammation Models: Used to establish controlled in vitro and in vivo models of endotoxin-induced inflammation for drug discovery.
• Reference Standard: Serves as a high-purity analytical standard for the qualification and quantification of lipid A and related compounds.
• Biochemical Reagent: Employed in structural-activity relationship (SAR) studies to understand the molecular basis of endotoxin activity.
• Cell Signaling Studies: A precise tool for activating specific immune cell lines (e.g., macrophages, dendritic cells) in signal transduction research.

Basic Information

Item	Detail
Product Name	2-Deoxy-2-[(R)-3-[(R)-3-Hydroxytetradecanoyloxy]Tetradecanoylamino]-3-o-[(R)-3-(Tetradecanoyloxy)Tetradecanoyl]-α-D-Glucopyranose 4-Phosphoric Acid
CAS No.	137245-42-2
Molecular Formula	C68H128N2O19P
Molecular Weight	1300.73 g/mol
Synonyms	Synthetic Lipid A (Compound 506); LA-15-PP; Monophosphoryl Lipid A (MPLA) analog; TLR4 Agonist; 2-Deoxy-2-[(3R)-3-[(3R)-3-hydroxytetradecanoyloxy]tetradecanoylamino]-3-O-[(3R)-3-(tetradecanoyloxy)tetradecanoyl]-α-D-glucopyranose 4-(dihydrogen phosphate); Bacterial Endotoxin Mimetic; Phosphorylated Hexaacyl Disaccharide
EINECS	Contact for details

Quality Control

This high-value biochemical is manufactured under strict GMP-like conditions to ensure batch-to-batch consistency and traceability. Every lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the exacting standards required for research and pharmaceutical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Endotoxin Activity (LAL)	Specified per batch
Biological Activity (Cell-based assay)	Reported per batch

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.