Description

2-Deoxy-2-[(R)-3-Hydroxytetradecanoylamino]-3-o-[(R)-3-[(R)-3-Hydroxytetradecanoyloxy]Tetradecanoyl]-α-D-Glucopyranose 4-Phosphoric Acid is a sophisticated synthetic lipid A derivative, a key structural component of bacterial endotoxins. This compound is of critical importance in immunological research and pharmaceutical development, serving as a high-purity reference standard and a potent Toll-like receptor 4 (TLR4) agonist. It is primarily required by research institutions, diagnostic manufacturers, and biopharmaceutical companies engaged in vaccine adjuvant development, sepsis research, and innate immunity studies.

Application

• Immunological Research: As a defined TLR4/MD-2 agonist for studying innate immune signaling pathways, cytokine induction, and inflammatory responses.
• Vaccine Adjuvant Development: A critical component in the formulation of next-generation vaccine adjuvants to enhance immunogenicity.
• Reference Standard: Used as an analytical standard in quality control and assay development for endotoxin detection (LAL tests) and related products.
• Sepsis and Inflammation Models: Employed in preclinical research to establish models of septic shock and systemic inflammation.
• Diagnostic Reagent Manufacturing: A key raw material in the production of in-vitro diagnostic (IVD) kits for endotoxin quantification and immune function assays.
• Drug Discovery Screening: Used in high-throughput screening platforms to identify novel anti-inflammatory compounds or TLR4 pathway modulators.

Basic Information

Product Name	2-Deoxy-2-[(R)-3-Hydroxytetradecanoylamino]-3-o-[(R)-3-[(R)-3-Hydroxytetradecanoyloxy]Tetradecanoyl]-α-D-Glucopyranose 4-Phosphoric Acid
CAS No.	137245-41-1
Molecular Formula	C53H100N2O19P
Molecular Weight	1107.33 g/mol
Synonyms	Lipid A (E. coli, synthetic); Monophosphoryl Lipid A (MPLA, synthetic); TLR4 Agonist (synthetic); (2R)-2-[[(2R)-3-Hydroxytetradecanoyl]amino]-3-[[(2R)-3-[(2R)-3-hydroxytetradecanoyloxy]tetradecanoyl]oxy]-4-phosphonooxy-6-(hydroxymethyl)oxan-2-yl]methyl hydrogen phosphate; Synthetic Endotoxin; GLA (Glucopyranosyl Lipid Adjuvant) related compound; Phosphorylated Hexaacyl Disaccharide
EINECS	Contact for details

Quality Control

Our synthetic Lipid A derivative is manufactured under strict quality systems. Each batch undergoes comprehensive analytical characterization including HPLC purity, mass spectrometry for identity confirmation, and endotoxin activity validation to ensure batch-to-batch consistency and biological potency. Certificates of Analysis (COA) detailing all specifications and test results are provided and can be tailored to meet specific GMP or research-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, desiccate at -20°C. Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (IR)	Conforms to structure
Identification (MS)	Conforms (M-H)-
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Specific Optical Rotation	Contact for details
Biological Activity (TLR4 assay)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.