Description

2'-o-(4-Benzoylbenzoyl)Guanosine Cyclic 3',5'-Monophosphate is a chemically modified derivative of cyclic GMP (cGMP), designed as a potent and cell-permeable activator of cGMP-dependent protein kinase (PKG). This compound is a critical research tool for investigating intracellular signaling pathways, particularly those mediated by nitric oxide and natriuretic peptides. It is essential for scientists in pharmaceutical R&D and academic biochemistry studying cardiovascular function, smooth muscle relaxation, and neurological processes.

Application

• Biochemical Research: A key tool for studying the role of cGMP and PKG in cellular signal transduction pathways.
• Pharmaceutical Development: Used in high-throughput screening and target validation for drugs targeting cardiovascular diseases, such as hypertension and pulmonary arterial hypertension.
• Cell Biology Studies: Employed to probe mechanisms of smooth muscle relaxation, platelet aggregation inhibition, and neuronal plasticity.
• Enzyme Activation Studies: Serves as a specific and potent activator for in vitro and in-cell assays of cGMP-dependent protein kinase activity.
• Vasodilation Research: Fundamental for investigating endothelial function and the nitric oxide (NO)-cGMP pathway in vascular biology.

Basic Information

Product Name	2'-o-(4-Benzoylbenzoyl)Guanosine Cyclic 3',5'-Monophosphate
CAS No.	137154-74-6
Molecular Formula	C28H25N5O10P
Molecular Weight	622.50 g/mol
Synonyms	2'-O-(4-Benzoylbenzoyl)-cGMP; BzBz-cGMP; 2'-O-(4-Benzoylbenzoyl)guanosine 3',5'-cyclic monophosphate; cGMP, 2'-O-(4-benzoylbenzoyl)-; PKG Activator; 2'-O-(p-Benzoylbenzoyl)-cGMP; Bz2Bz-cGMP; 2'-O-(4-Benzoylbenzoyl)-guanosine-3',5'-cyclic monophosphate
EINECS	Contact for details

Quality Control

Our 2'-o-(4-Benzoylbenzoyl)Guanosine Cyclic 3',5'-Monophosphate is manufactured under strict quality systems suitable for research use. Each batch is characterized and tested to ensure identity, purity, and biological activity. A comprehensive Certificate of Analysis (COA) detailing results from HPLC, NMR, and MS is provided with every shipment to guarantee traceability and consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.