Description

Tentagel Resin CAS NO 136841-34-4 is a high-performance, functionalized polystyrene-polyethylene glycol (PS-PEG) graft copolymer resin widely used as a solid support for solid-phase synthesis. This versatile material is engineered to combine the robust mechanical properties of polystyrene with the superior solvation characteristics of polyethylene glycol, enabling high-efficiency reactions in diverse solvent systems. It is an essential tool for researchers and manufacturers in the pharmaceutical, biotechnology, and combinatorial chemistry sectors, facilitating the synthesis of peptides, small molecules, and other complex organic compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A primary support resin for the efficient, automated synthesis of peptides, from small fragments to complex polypeptides.
• Combinatorial Library Generation: Enables the parallel synthesis of vast libraries of small molecules for high-throughput screening in drug discovery.
• Oligonucleotide Synthesis: Used as a solid support in the phosphoramidite method for synthesizing DNA and RNA fragments.
• Organic Synthesis Scaffold: Supports a wide range of organic transformations, including Mitsunobu reactions, alkylations, and palladium-catalyzed couplings.
• Enzyme and Protein Immobilization: Serves as a functionalized matrix for immobilizing biocatalysts for use in industrial bioprocesses and biosensors.
• High-Throughput Purification: Employed in scavenger resin applications to remove excess reagents or by-products from reaction mixtures.

Basic Information

Product Name	Tentagel Resin
CAS No.	136841-34-4
Molecular Formula	(C8H8)n-(C2H4O)m
Molecular Weight	Variable (Polymer)
Synonyms	TentaGel; Polystyrene-poly(ethylene glycol) graft copolymer; PS-PEG resin; PEG-PS resin; Poly(ethylene glycol)-grafted polystyrene; Tentagel S; TGR; TG resin; PEGylated polystyrene resin; Solid-phase synthesis resin
EINECS	Contact for details

Quality Control

Our Tentagel Resin is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure consistent performance, including measurement of loading capacity, bead size distribution, and swelling properties. Certificates of Analysis (COA) detailing specifications such as functional group loading (mmol/g), particle size, and solvent compatibility are provided with every shipment to guarantee reproducibility and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after use to prevent moisture uptake, which can affect performance. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white spherical beads
Bead Size	75-150 μm (or as specified)
Loading Capacity	0.2 - 0.6 mmol/g (variable by functionalization)
Swelling Volume	≥ 5 mL/g in DMF
Functional Group	Rink Amide, Wang, MBHA, etc. (as specified)
Purity (by HPLC)	≥ 95% (for cleaved standard peptide)
Moisture Content	< 5% (by KF titration)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.