Description

(+/-)-Norpropoxyphene-D5 Maleate CAS NO 136765-47-4 is a deuterated internal standard of high analytical importance. This compound is critical for ensuring accuracy and precision in quantitative mass spectrometry-based analyses. It is primarily required by pharmaceutical research and development laboratories, forensic toxicology units, and contract research organizations (CROs) for method development and validation.

Application

• Quantitative Internal Standard for LC-MS/MS: Essential for the accurate quantification of non-deuterated norpropoxyphene and related metabolites in complex biological matrices such as plasma, serum, and urine.
• Forensic and Clinical Toxicology: Used in method development and routine testing for the detection and confirmation of propoxyphene abuse or overdose cases.
• Pharmacokinetic and Metabolism Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) in preclinical and clinical research.
• Pharmaceutical Quality Control: Supports impurity profiling and stability-indicating assay methods for drug substance and finished product analysis.
• Reference Material for Method Validation: Serves as a certified reference material to validate analytical procedures according to ICH, FDA, and other regulatory guidelines.

Basic Information

Product Name	(+/-)-Norpropoxyphene-D5 Maleate
CAS No.	136765-47-4
Molecular Formula	C₂₂H₂₅D₅NO₄ • C₄H₄O₄
Molecular Weight	~ 467.6 g/mol
Synonyms	Norpropoxyphene-d5 Maleate; α-d5-Norpropoxyphene Maleate; DL-Norpropoxyphene-d5 Maleate; 2-(Dimethylamino)-1,2-diphenylethyl-d5 Propionate Maleate; Dextropropoxyphene Metabolite-d5 Maleate; (2S,3R)-3-(Dimethylamino)-2-methyl-1,1-diphenylpropan-1-ol-d5 Propionate Maleate; α-Acetylmethadol-d5 Metabolite Maleate
EINECS	Contact for details

Quality Control

Every batch of (+/-)-Norpropoxyphene-D5 Maleate is manufactured and tested under strict quality management systems. We guarantee high chemical and isotopic purity to meet the exacting demands of analytical reference standards. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing results for assay, isotopic enrichment, and impurity profiles. Our quality commitment aligns with the standards expected for pharmaceutical reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, ideally between 15-25°C. Keep the container in a dry environment to maintain stability. For long-term storage, consider storing desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-content)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH limits
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.