Description

Spermine NONOate is a nitric oxide (NO) donor compound that spontaneously releases NO under physiological conditions. This molecule is of significant value in biochemical and pharmacological research for studying the complex signaling pathways mediated by nitric oxide. It is primarily needed by researchers and developers in the life sciences, pharmaceutical R&D, and academic institutions focused on cardiovascular, neurological, and cellular signaling studies.

Application

• Biochemical Research: Used as a reliable source of nitric oxide to study its role as a signaling molecule in various biological systems.
• Vasodilation Studies: Applied in cardiovascular research to investigate NO-induced relaxation of vascular smooth muscle.
• Neurobiology: Employed to examine the effects of NO on neuronal function, synaptic plasticity, and neuroprotection.
• Cell Signaling Pathways: A critical tool for dissecting cGMP-mediated signaling cascades triggered by nitric oxide release.
• Pharmaceutical Screening: Serves as a reference compound in drug discovery programs targeting NO-related pathologies.
• Inflammation and Immunology Research: Used to model the immunomodulatory and cytotoxic effects of nitric oxide.

Basic Information

Product Name	Spermine NONOate
CAS No.	136587-13-8
Molecular Formula	C10H26N6O2
Molecular Weight	262.36 g/mol
Synonyms	Spermine Diazeniumdiolate; N-(3-Aminopropyl)-N-(4-(3-aminopropylamino)butyl)diazen-1-ium-1,2-diolate; Spermine/NO; Spermine Nitric Oxide Complex; Sper/NO; 1,1-Diethyl-2-hydroxy-2-nitrosohydrazine, Spermine Derivative; Norspermine NONOate (related analog)
EINECS	Contact for details

Quality Control

Our Spermine NONOate is produced under strict quality protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability data. We adhere to ISO 9001 quality management standards, and our analytical methods are validated to meet the rigorous demands of the research community.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term stability, store under an inert atmosphere such as argon or nitrogen. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 98%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Nitric Oxide Release	1.5 - 2.0 moles NO per mole compound
Solubility	Soluble in aqueous buffer (pH 7.4), DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.