Description

2-Amino-4-Hydroxy-7-(Dihydroxypropyl)-5,6,7,8-Tetrahydrobiopterin is a high-purity, chemically synthesized derivative of tetrahydrobiopterin (BH4), a critical cofactor for aromatic amino acid hydroxylases and nitric oxide synthases. This compound is essential for research and development in biochemistry and pharmaceutical sciences, where precise enzymatic function and metabolic pathway studies are required. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and manufacturers of diagnostic reagents and fine chemicals.

Application

• Pharmaceutical Research & Development: As a key intermediate or reference standard in the synthesis of novel therapeutics targeting metabolic disorders, cardiovascular diseases, and neurological conditions.
• Enzymology Studies: Serving as a vital cofactor in in vitro assays to study the activity of phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH), and nitric oxide synthase (NOS).
• Diagnostic Reagent Manufacturing: Used in the formulation of diagnostic kits for the detection and quantification of related enzymes or metabolites in clinical samples.
• Biochemical Reference Standard: Providing a high-purity standard for analytical method development, validation, and quality control in laboratory settings.
• Cell Culture & Neuroscience Research: Investigating its role in neurotransmitter synthesis and cellular signaling pathways within specialized research models.

Basic Information

Item	Details
Product Name	2-Amino-4-Hydroxy-7-(Dihydroxypropyl)-5,6,7,8-Tetrahydrobiopterin
CAS No.	136459-42-2
Molecular Formula	C9H17N5O5
Molecular Weight	275.26 g/mol
Synonyms	7-(Dihydroxypropyl)-2-amino-4-hydroxy-5,6,7,8-tetrahydrobiopterin; 6-(L-erythro-1,2-Dihydroxypropyl)-5,6,7,8-tetrahydropterin; 6-(1,2-Dihydroxypropyl)-5,6,7,8-tetrahydropterin; 7,8-Dihydro-6-[(1S,2S)-1,2-dihydroxypropyl]pterin-2,4-diamine; Tetrahydrobiopterin derivative; BH4 derivative; 6-Dihydroxypropyl-5,6,7,8-tetrahydropterin
EINECS	Contact for details

Quality Control

Our 2-Amino-4-Hydroxy-7-(Dihydroxypropyl)-5,6,7,8-Tetrahydrobiopterin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a desiccated environment. For long-term stability, consider storage under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.