Description

Methotrexate-N,N'-Bis(Decylamide) CAS NO 136181-93-6 is a chemically modified derivative of the antifolate agent methotrexate, designed to alter its physicochemical properties and biological activity profile. This compound is of significant interest for advanced pharmaceutical research and development, particularly in the exploration of novel drug delivery systems and targeted therapeutic agents. It serves as a critical intermediate or active pharmaceutical ingredient (API) for researchers and manufacturers in the oncology and immunology sectors, focusing on next-generation treatments.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of novel methotrexate prodrugs and conjugates for enhanced therapeutic efficacy.
• Oncology Research: Used in preclinical studies to develop targeted cancer therapies with modified pharmacokinetics and reduced systemic toxicity.
• Drug Delivery Systems: Incorporated into liposomal, polymeric, or nanoparticle formulations to improve solubility, stability, and tissue-specific targeting.
• Biochemical Research: Acts as a tool compound for studying folate metabolism inhibition and enzyme (dihydrofolate reductase) interactions in cellular models.
• Immunosuppressant Development: Explored for creating new analogs with potential applications in autoimmune disease management.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Methotrexate-N,N'-Bis(Decylamide)
CAS No.	136181-93-6
Molecular Formula	C39H62N8O5
Molecular Weight	722.97 g/mol
Synonyms	N,N'-Didecylmethotrexamide; Methotrexate Didecylamide; MTX-Bis(Decylamide); L-Glutamic acid, N-[4-[[(2,4-diamino-6-pteridinyl)methyl]methylamino]benzoyl]-, 1-(decylamide), 5-(decylamide); 4-Amino-10-methylpteroyl-N,N'-didecyl diglutamate; Amethopterin N,N'-bis(decylamide)
EINECS	Contact for details

Quality Control

Our Methotrexate-N,N'-Bis(Decylamide) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment ensures material suitable for research and development applications under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a desiccated environment away from direct light exposure to maintain stability and purity.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.