Description

n-(3-(4-Azido-3-Iodophenyl)-Propionamide)-7-Aminoethylcarbamyl-7-Desacetylforskolin is a specialized, high-purity chemical derivative of forskolin, designed for advanced biochemical research and pharmaceutical development. This compound is engineered as a potent, photoactivatable cross-linking agent, enabling researchers to study and map protein-protein interactions and receptor binding sites with high precision. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies focused on signal transduction pathways, adenylate cyclase activation, and targeted drug discovery.

Application

• Photoaffinity Labeling: Acts as a critical tool for covalently tagging and identifying biological targets, such as adenylate cyclase and other forskolin-binding proteins, upon UV light activation.
• Biochemical Research: Used in mechanistic studies of cAMP signaling pathways and G-protein coupled receptor (GPCR) function.
• Proteomics and Target Identification: Facilitates the discovery and validation of novel drug targets by irreversibly binding to active sites.
• Pharmaceutical Development: Serves as a key intermediate or probe in the design of new therapeutic agents targeting metabolic and cardiovascular diseases.
• Molecular Biology Studies: Employed to investigate enzyme kinetics and allosteric regulation through its specific binding properties.
• Diagnostic Reagent Synthesis: Can be used in the development of specialized assays and diagnostic tools for cellular function analysis.

Basic Information

Product Name	n-(3-(4-Azido-3-Iodophenyl)-Propionamide)-7-Aminoethylcarbamyl-7-Desacetylforskolin
CAS No.	136133-69-2
Molecular Formula	C31H36IN7O5
Molecular Weight	737.56 g/mol
Synonyms	7-Desacetyl-7-[N-(3-(4-azido-3-iodophenyl)propionamido)ethylcarbamoyl]forskolin; 7-Desacetylforskolin azido-iodophenyl derivative; Photoactivatable forskolin derivative; cAMP pathway photoaffinity probe; 7-[2-[[3-(4-Azido-3-iodophenyl)-1-oxopropyl]amino]ethyl]aminocarbonyl-7-desacetylforskolin; Forskolin-based crosslinker; AC activator probe
EINECS	Contact for details

Quality Control

This high-grade biochemical is manufactured under strict quality protocols to ensure exceptional purity and batch-to-batch consistency, critical for sensitive research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and stability is provided with every shipment to support your research documentation and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. The product is light-sensitive (store away from light). Allow the vial to reach room temperature in the dark before opening to minimize condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.