Description

(S,R)-Palonosetron Hydrochloride CAS NO 135729-76-9 is a high-purity, non-racemic stereoisomer of the potent 5-HT3 receptor antagonist palonosetron. This compound is of significant value as a key chiral intermediate or reference standard in advanced pharmaceutical research and development. It is primarily needed by pharmaceutical manufacturers and R&D laboratories focused on developing next-generation antiemetic therapies, particularly for chemotherapy-induced nausea and vomiting (CINV).

Application

• Pharmaceutical Active Pharmaceutical Ingredient (API) Synthesis: Serves as a critical chiral building block in the synthesis of stereochemically pure palonosetron hydrochloride.
• Reference Standard for Analytical Development: Used in HPLC, LC-MS, and other chromatographic methods for method validation, impurity profiling, and quality control of palonosetron-based drugs.
• Pharmacological Research: Employed in preclinical studies to investigate the structure-activity relationship (SAR) and stereospecific efficacy of 5-HT3 receptor antagonists.
• Process Chemistry & Route Scouting: Utilized in the development and optimization of asymmetric synthesis pathways for complex pharmaceutical molecules.
• Regulatory Submission Support: Acts as a characterized impurity or degradation product standard for regulatory filings (e.g., with FDA, EMA).

Basic Information

Product Name	(S,R)-Palonosetron Hydrochloride
CAS No.	135729-76-9
Molecular Formula	C19H24N2O•HCl
Molecular Weight	332.87 g/mol (Free base: 296.41)
Synonyms	(3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride; Palonosetron (S,R)-isomer Hydrochloride; (S,R)-Palonosetron HCl; UNII-6M9P6KZ6NN (isomer); Aloxi® Isomer Intermediate; RS-Palonosetron Hydrochloride
EINECS	Contact for details

Quality Control

Our (S,R)-Palonosetron Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets stringent specifications for pharmaceutical R&D use. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (S,R Isomer)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.