Description

Palonosetron Hcl CAS NO 135729-75-8 is a high-purity, second-generation 5-HT3 receptor antagonist used as an active pharmaceutical ingredient (API). It is valued for its superior efficacy and longer half-life in preventing chemotherapy-induced and post-operative nausea and vomiting (CINV and PONV). This compound is essential for pharmaceutical manufacturers developing injectable and oral antiemetic formulations, targeting oncology, surgical, and clinical research applications.

Application

• Primary Active Pharmaceutical Ingredient (API) in injectable antiemetic drugs.
• Formulation of oral dosage forms, such as tablets and capsules, for CINV prevention.
• Key component in combination therapy regimens for enhanced nausea control.
• Use in clinical research and development of new antiemetic therapies.
• Manufacturing of generic pharmaceutical products following patent expiry.
• Preparation of analytical reference standards for quality control laboratories.

Basic Information

Product Name	Palonosetron Hcl
CAS No.	135729-75-8
Molecular Formula	C19H24N2O•HCl
Molecular Weight	332.87 g/mol (as hydrochloride)
Synonyms	Palonosetron Hydrochloride; (3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride; RS-25259-197; Aloxi (Brand Name); Palonosetron HCl; Palonosetron Monohydrochloride
EINECS	Contact for details

Quality Control

Our Palonosetron Hcl is manufactured under strict quality systems suitable for pharmaceutical applications. It undergoes rigorous analytical testing, including HPLC, IR, and residual solvent analysis, to ensure compliance with high-purity pharmacopeial standards (e.g., USP, EP). A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each batch to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.