Description

Palonosetron Hydrochloride CAS NO 135729-62-3 is a highly potent and selective second-generation 5-HT₃ receptor antagonist. It is a critical active pharmaceutical ingredient (API) valued for its superior efficacy and longer half-life compared to earlier antiemetics. This compound is essential for pharmaceutical manufacturers developing injectable and oral formulations to prevent chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV).

Application

• Primary Active Pharmaceutical Ingredient (API) in injectable antiemetic formulations.
• Core component in the manufacture of oral dosage forms such as tablets and capsules.
• Used in oncology supportive care drugs for the prevention of acute and delayed CINV.
• Key ingredient in medications for the prevention of postoperative nausea and vomiting (PONV).
• Utilized in pharmaceutical research and development for new antiemetic therapies.
• Employed in the production of generic pharmaceutical products.
• Serves as a reference standard in analytical and quality control laboratories.

Basic Information

Product Name	Palonosetron Hydrochloride
CAS No.	135729-62-3
Molecular Formula	C19H24N2O·HCl
Molecular Weight	332.87 g/mol (Free base: 296.41)
Synonyms	(3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one Hydrochloride; Palonosetron HCl; RS-25259-197; Aloxi (Brand Name); Onicit; Paloxi; Palosetron Hydrochloride; Palonosetronum
EINECS	Contact for details

Quality Control

Our Palonosetron Hydrochloride is manufactured under strict quality systems. It is typically tested to meet high-purity standards suitable for pharmaceutical applications, with specifications aligning with major pharmacopoeial guidelines. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.