Description

Palonosetron is a highly potent and selective second-generation 5-HT₃ receptor antagonist. This compound is critical for the effective prevention of chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea and vomiting (PONV). It is an essential active pharmaceutical ingredient (API) for pharmaceutical manufacturers developing injectable and oral antiemetic formulations. Palonosetron CAS NO 135729-61-2 offers superior efficacy and a longer half-life compared to first-generation agents.

Application

• Primary Pharmaceutical API: Core active ingredient in injectable solutions and oral capsules/tablets for the prevention of acute and delayed CINV.
• Oncology Supportive Care: Formulated for administration prior to moderately or highly emetogenic cancer chemotherapy regimens.
• Surgical Care: Used in formulations to prevent and treat nausea and vomiting following surgical procedures.
• Drug Product Development: Serves as the key component for generic and innovative drug product development in the antiemetic therapeutic area.
• Clinical Research: Used as a reference standard and raw material in pharmacokinetic and pharmacodynamic studies.
• Combination Therapies: Employed in the development of fixed-dose combination products with other supportive care agents like neurokinin-1 (NK₁) receptor antagonists.

Basic Information

Product Name	Palonosetron
CAS No.	135729-61-2
Molecular Formula	C19H24N2O
Molecular Weight	296.41 g/mol
Synonyms	Palonosetron Hydrochloride (common salt form); (3aS)-2-[(3S)-1-Azabicyclo[2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1H-benz[de]isoquinolin-1-one; RS-25259-197; Aloxi® (brand name); Onicit; Paloxi; 5-HT3 receptor antagonist
EINECS	Contact for details

Quality Control

Our Palonosetron is manufactured under strict quality management systems. It is produced to meet high-purity standards suitable for pharmaceutical applications, with typical specifications aligning with major pharmacopoeial requirements. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We ensure traceability and compliance with cGMP principles and relevant ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. The container should be kept tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time corresponds to reference
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity: ≤ 0.5% Total impurities: ≤ 1.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.